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Merck

SCP0093

Sigma-Aldrich

Caspase Inhibitor

≥95% (HPLC)

别名:

Ac-LETD-CHO, caspase 8 inhibitor, caspase 9 inhibitor

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About This Item

经验公式(希尔记法):
C21H34N4O10
分子量:
502.52
分類程式碼代碼:
12352200
NACRES:
NA.32

化驗

≥95% (HPLC)

形狀

lyophilized

成份

Peptide Content, ≥80%

儲存條件

protect from light

儲存溫度

−20°C

基因資訊

Amino Acid Sequence

Ac-Leu-Glu-Thr-Asp-al

應用

Caspase 抑制剂 Ac-LETD-CHO 已被用于抑制胱天蛋白酶-8。

生化/生理作用

肽 Ac-Leu-Glu-Thr-Asp-al 或 Ac-LETD-CHO 是一种已知的半胱天冬酶抑制剂。据报道,Ac-LETD-CHO 对半胱天冬酶 8 和半胱天冬酶 9 具有抑制作用。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Preventive Effects of Food Components on Caspase-8-Mediated Apoptosis Induced by Dietary Carcinogen, Trp-P-1, in Rat Mononuclear Cells
Hashimoto, T., et al.
ACS Symp. Ser., 851, 128-140 (2003)
Jie Shi et al.
Biochemical pharmacology, 75(9), 1729-1742 (2008-04-02)
Indirubin-3'-monoxime (I3M) is a derivative of indirubin, an active component from a Chinese medicinal recipe with known anti-cancer function. I3M has been well established as a cyclin-dependent kinase (CDK) inhibitor, while the molecular mechanism underlying I3M-induced apoptosis has not been
Takashi Araki et al.
Nephron. Experimental nephrology, 93(3), e117-e124 (2003-03-28)
Programmed cell death is a mechanism by which organisms dispose of unwanted cells, and it is thought to be an important process in organogenesis. We have already reported the role of caspase-3 in the developing metanephros. While caspase-3 is thought
Enteric glial cells counteract Clostridium difficile Toxin B through a NADPH oxidase/ROS/JNK/caspase-3 axis, without involving mitochondrial pathways
Lara M
Scientific Reports (2017)
Apoptotic Regulation of Caspase Activity
Martinova, E.A., et al.
Russian J. Bioorg. Chem., 29, 471-495 (2003)

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