SAB5700279

Anti-Phospho-ATM-S1981 antibody produced in rabbit

• 别名: AT1, ATA, ATC, ATD, ATDC, ATE, ATM, TEL1, TELO1
• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100
• 抗体形式: affinity isolated antibody
• 抗体产品类型: primary antibodies
• 克隆: polyclonal
• 表单: buffered aqueous solution
• 分子量: 350
• 种属反应性: human
• 浓度: 1.02 mg/ml
• 技术: immunofluorescence: 1:50-1:200; western blot: 1:500-1:2000
• UniProt登记号: Q13315
• 运输: wet ice
• 储存温度: −20°C
• 靶向翻译后修饰: phosphorylation (pSer1981)
• 基因信息: human ... ATM(472)

说明

一般描述

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

免疫原

A synthetic phosphorylated peptide around S1981 of human ATM (NP_000042.3).

外形

PBS with 0.02% sodium azide,50% glycerol,pH7.3.

储存及稳定性

Store at -20℃. Avoid freeze / thaw cycles.

安全信息

• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable