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生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 16 kDa
种属反应性
human, rat, mouse
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CALM1(801)
一般描述
Anti-Calmodulin Antibody detects endogenous levels of total Calmodulin protein.
Calmodulin (CaM), a highly conserved Ca2+-binding protein, is mapped to human chromosome 14q32. Calmodulin is a small protein abundantly present in the brain and coded by three genes (CALM1-3).
Calmodulin (CaM), a highly conserved Ca2+-binding protein, is mapped to human chromosome 14q32. Calmodulin is a small protein abundantly present in the brain and coded by three genes (CALM1-3).
免疫原
The antiserum was produced against synthesized peptide derived from human Calmodulin.
Immunogen Range: 46-95
Immunogen Range: 46-95
应用
Anti-Calmodulin antibody has been used in western blotting.
生化/生理作用
Calmodulin (CaM) possesses Ca2+-dependent modulatory roles. It participates in cell proliferation and muscle activity. Calmodulin plays a major role in catecholaminergic polymorphic ventricular tachycardia (CPVT) and in long QT syndrome (LQTS). This protein modulates the transcriptional processes required for proper heart function.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Orthologs of seven genes (AKT1, CDC42BPB, DIO3, EIF5, JAG2, KLC, NDUFB1) from human chromosome 14q32 map to distal chicken chromosome 5.
Boyd Y, et al.
Mammalian Genome, 13(2), 120-122 (2002)
Presynaptic Calmodulin targets: lessons from structural proteomics.
Lipstein N, et al.
Expert Review of Proteomics, 14(3), 223-242 (2017)
Chunhong Song et al.
BioMed research international, 2017, 8459287-8459287 (2018-01-25)
The aim of this study was to explore the mechanism underlying the antidepression activity of paeoniflorin, the main active ingredient of paeony extract and Shuyu capsules, and determine its effect on the calmodulin/calmodulin-dependent protein kinase II (CaM/CaMKII) signalling pathway and
Ruizhen Li et al.
Molecular biology of the cell, 27(21), 3273-3283 (2016-11-02)
Intracellular calcium transients are a universal phenomenon at fertilization and are required for egg activation, but the exact role of Ca2+ in second-polar-body emission remains unknown. On the other hand, similar calcium transients have not been demonstrated during oocyte maturation
The Arrhythmogenic Calmodulin Mutation D129G Dysregulates Cell Growth, Calmodulin-dependent Kinase II Activity and Cardiac Function in Zebrafish.
Berchtold MW, et al.
The Journal of Biological Chemistry, 291(52), 26636?26646-26636?26646 (2016)
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