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生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
64 kDa
物種活性
rat, human, mouse
濃度
1.0 mg/mL
技術
immunohistochemistry: 1:50-1:100
同型
IgG
登錄號
NP_002126.2.
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer351)
基因資訊
human ... NR4A1(3164)
一般說明
Nuclear receptor subfamily 4 group A member 1 (NR4A1) also known as nuclear hormone receptor 77 (NUR77), belongs to NR4A subfamily nuclear hormone receptors. In human chromosome, the gene NR4A1 is localized on 12q13.13.
特異性
The antibody detects endogenous levels of Nuclear Receptor NR4A1 only when phosphorylated at serine 351
免疫原
Peptide sequence around phosphorylation site of Serine351(L-P-S(p)-K-P) derived from Human Nuclear Receptor NR4A1.
生化／生理作用
Nuclear receptor subfamily 4 group A member 1 (NR4A1) is essential for regulation of cell proliferation, apoptosis and energy metabolism. Nur77 is an acetylated protein, modulated by histone acetyltransferase p300 (p300) and histone deacetylase 1 (HDAC1) for its rapid turnover. Nur77 regulates liver kinase B1 (LKB1)- AMP (adenosine monophosphate)-activated protein kinase (AMPK) and plays a major role in glucose metabolism. Expression of Nur77 in skeletal muscle promotes glucose uptake by enhancing insulin pathway and upregulates glycolysis pathway. Expression of Nur77 in hepatocytes promotes gluconeogenesis. Mutation in Nur77 may result in diet-induced obesity and insulin resistance in tissues. Nur77 is a potential drug target for metabolic disorders. NR4A1 is an anti-oncogenic protein that reduces the tumour cell proliferation and metastasis. NR4A1 increases the gastric cancer cells sensitivity towards tumour necrosis factor α (TNF-α) mediated apoptotic pathway. NR4A1 is downregulated in breast cancer, leukemia. NR4A1 plays a crucial role and a potent therapeutic target for fibrosis of endometriosis.
特點和優勢
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外觀
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
NR4A1 is Involved in Fibrogenesis in Ovarian Endometriosis
Zeng X, et al.
Cellular Physiology and Biochemistry, 46(3), 1078-1090 (2018)
NR4A1-induced increase in the sensitivity of a human gastric cancer line to TNF alpha-mediated apoptosis is associated with the inhibition of JNK/Parkin-dependent mitophagy
Yan H, et al.
International Journal of Oncology, 52(2), 367-378 (2018)
Regulation of Nur77 protein turnover through acetylation and deacetylation induced by p300 and HDAC1
Kang SA, et al.
Biochemical Pharmacology, 80(6), 867-873 (2010)
The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
Zhan YY, et al.
Nature Chemical Biology, 8(11), 897-904 (2012)
Merlin G Butler et al.
International journal of molecular sciences, 16(3), 6464-6495 (2015-03-25)
Recently, autism-related research has focused on the identification of various genes and disturbed pathways causing the genetically heterogeneous group of autism spectrum disorders (ASD). The list of autism-related genes has significantly increased due to better awareness with advances in genetic
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