价格与库存信息目前不能提供
推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
buffered aqueous solution
分子量
~88 kDa
物種活性
mouse, human, rat
濃度
1 mg/mL
技術
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同型
IgG
免疫原序列
(P-M-SP-P-R)
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
目標翻譯後修改
phosphorylation (pSer727)
基因資訊
human ... STAT3(6774)
一般說明
信号传感器和转录激活因子3 (STAT3)是白介素-6- (IL-6)激活的急性期反应因子(APRF)复合物的组成部分，属于信号传感器和转录激活因子(STAT)家族。在所有类型的组织中都有表达。STAT3基因有24个外显子，定位于人类染色体17q21.2。
免疫原
基于蛋白质STAT3的丝氨酸727（PMS（p）-PR）磷酸化位点周围的肽序列。
生化／生理作用
信号传感器和转录激活因子3 (STAT3)蛋白在细胞生长、凋亡、代谢、细胞呼吸和自噬中起关键作用。它可能是糖皮质激素受体信号转导的共激活物。STAT3可调节转录。它参与脊椎动物的发育以及炎症和免疫的调节。可能参与气道炎症、过敏和哮喘。STAT3基因突变与免疫缺陷、自身免疫和癌症相关。
特點和優勢
您可完全放心的评估我们的抗体。如果抗体在您的应用中没有发挥效果，我们将给予您完全的赔偿或更换抗体。 了解更多。
標靶描述
能与多种急性期蛋白基因启动子中所鉴定的白介素6（IL-6）反应元件结合的转录因子。其可由IL31通过IL31RA进行激活。
外觀
溶于含有0.02％叠氮化钠和50%甘油的磷酸盐缓冲盐水
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
未找到合适的产品？
试试我们的产品选型工具.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Fabian Gärtner et al.
Frontiers in immunology, 12, 745132-745132 (2021-12-07)
Thoracic traumas with extra-thoracic injuries result in an immediate, complex host response. The immune response requires tight regulation and can be influenced by additional risk factors such as obesity, which is considered a state of chronic inflammation. Utilizing high-dimensional mass
Kayvan Saeedfar et al.
Tanaffos, 16(1), 1-8 (2017-06-24)
Despite being a high burden disorder, the pathogenesis of severe refractory asthma (SRA) is poorly understood. There are some evidences for the involvement of members of the signal transducer and activator of transcription (STAT) family, including STAT3 and STAT5a. Our
Emily J Hillmer et al.
Cytokine & growth factor reviews, 31, 1-15 (2016-05-18)
The transcriptional regulator STAT3 has key roles in vertebrate development and mature tissue function including control of inflammation and immunity. Mutations in human STAT3 associate with diseases such as immunodeficiency, autoimmunity and cancer. Strikingly, however, either hyperactivation or inactivation of
Akanksha Khandelwal et al.
Cancer science, 111(3), 826-839 (2019-09-15)
Despite the availability of various diagnostic procedures, a tissue biopsy is still indispensable for the routine diagnosis of lung cancer. However, inaccurate diagnoses can occur, leading to inefficient cancer management. In this context, use of circulating microRNAs (miRNAs) may serve
Rossana Cocchiola et al.
International journal of molecular sciences, 20(8) (2019-04-25)
STAT3 is an oncoprotein overexpressed in different types of tumors, including prostate cancer (PCa), and its activity is modulated by a variety of post-translational modifications (PTMs). Prostate cancer represents the most common cancer diagnosed in men, and each phase of
Active Filters
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门
