SAB4200778

Anti-NRAS Antibody

rabbit polyclonal

• 别名: Anti-GTPase NRas, Anti-transforming protein N-Ras
• 分類程式碼代碼: 12352203
• NACRES: NA.41

属性

• 产品名称: Anti-NRAS (internal) antibody produced in rabbit, affinity isolated antibody
• 生物源: rabbit
• 品質等級: 200
• 抗體表格: affinity isolated antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: polyclonal
• 形狀: buffered aqueous solution
• 分子量: predicted mol wt ~21 kDa
• 物種活性: human
• 濃度: ~1.0 mg/mL
• 技術: immunoblotting: 2.5-5 μg/mL using human MCF7 cell line extract; immunohistochemistry: 10-20 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human melanoma sections
• UniProt登錄號: P01111
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified
• 基因資訊: human ... NRAS(4893)

说明

一般說明

NRAS, also known as GTPase NRas, Transforming protein N-Ras, or Neuroblastoma RAS Viral (V-Ras) Oncogene Homolog, is a member of the Ras protein family, together with KRAS (Kirsten RAS), and HRAS (Harvey RAS), comprising a family of low-molecular-weight GTPases. The Ras family is named for a retrovirus that induced rat sarcomas that were later found to have activating RAS mutations. Ras family proteins serve as molecular switches in regulating pathways that are responsible for diverse cellular processes such as proliferation, differentiation, migration, and apoptosis.3 Ras proteins are highly homologous regarding their primary amino acid sequence and the differences among them concentrated in their C-terminal region. Anti-NRAS (internal) antibody produced in rabbit specifically recognizes human NRAS and does not cross-react with KRAS.

免疫原

Synthetic peptide from the internal region of human NRAS protein, conjugated to KLH

應用

The antibody may be used in various immunochemical techniques including immunoblotting (predicted ∼21 kDa) and immunohistochemistry. Detection of the NRAS band by Immunoblotting is specifically inhibited by the immunizing protein.

外觀

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative.

其他說明

This product is for R&D use only, not for drug, household, or other uses.

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable