SAB4200755

Anti-Human IgE-Peroxidase antibody, Mouse monoclonal

clone GE-1, purified from hybridoma cell culture

• 别名: Anti-Immunoglubulin E
• 分類程式碼代碼: 12352203
• NACRES: NA.46

属性

• 生物源: mouse
• 品質等級: 200
• 共軛: peroxidase conjugate
• 抗體表格: purified from hybridoma cell culture
• 抗體產品種類: primary antibodies
• 無性繁殖: GE-1, monoclonal
• 形狀: lyophilized powder
• 物種活性: human
• 技術: ELISA: 1:20,000-1:30,000 using 5 μg/mL Human IgE myeloma for coating
• 同型: IgG2b
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• 目標翻譯後修改: unmodified

说明

一般說明

Monoclonal Anti-Human IgE (mouse IgG2b isotype) is derived from the GE-1 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from a mouse immunized with purified human IgE myeloma protein. IgE (Immunoglobulin E) is the least abundant immunoglobulin isotype. IgE is produced by plasma cells and is highly functional in the lung, skin, and mucous membranes. Normal levels of IgE in serum are less than 1 μmL.

特異性

Monoclonal Anti-Human IgE specifically recognizes Human IgE. The antibody shows no cross-reactivity with human IgG1, IgG2, IgG3, IgG4, IgA, and IgM.

免疫原

Purified human IgE

應用

Anti-Human IgE-Peroxidase antibody has been used in enzyme linked immunosorbent assay (ELISA).

生化／生理作用

IgE plays a critical role in allergic reactions and host protection from parasites. During an allergic reaction such as atopic eczema, extrinsic asthma or hay fever, fungal and parasitic infection, atopic disease, or primary immunodeficiency the serum IgE levels can be induced up to 5-fold. IgE specifically and reversibly binds to the membrane receptor Fc-epsilon receptors (FcεR) type I on the surface of basophils, eosinophils, and mast cells. This binding activates the release of histamine, leukotrienes, and other mediators responsible for hypersensitivity. The recognition and isolation of allergen-specific IgE can lead to progress in understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders.

外觀

Supplied as a lyophilized powder.

其他說明

This product is for R&D use only, not for drug, household, or other uses.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable