推荐产品
生物源
rabbit
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
polyclonal
形狀
liquid
分子量
74 kDa
物種活性
mouse, rat, human
濃度
1 mg/mL
技術
immunocytochemistry: suitable
immunofluorescence: suitable
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
immunoprecipitation (IP): suitable
western blot: 500-10000
UniProt登錄號
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
human ... ACSL4(2182)
免疫原
与FACL4(Uniprot ID#O60488)的氨基酸649和711中的一个区域对应的合成肽
應用
建议的起始稀释度如下:ICC/IF:1:100-1:1000,免疫组化石蜡切片:1:100-1:1000, IP:1:1000-1:5000,蛋白质印迹:1:500-1:10000。尚未在其他应用中测试。最佳工作稀释度应由最终用户通过实验确定。
生化/生理作用
该基因编码的蛋白质是长链脂肪酸-辅酶A连接酶家族的同工酶。尽管底物特异性、亚细胞定位和组织分布不同,但该家族的所有同工酶均将游离的长链脂肪酸转化为脂肪酰基辅酶A酯,从而在脂质生物合成和脂肪酸降解中起关键作用。该同工酶优先利用花生四烯酸作为底物。这种酶的缺乏可能导致智力低下或Alport综合征。该基因的可变剪接产生2个转录物变体。[由 RefSeq 提供]
特點和優勢
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用,我们将全额退款或安排替代抗体。了解更多信息。
外觀
1XPBS,20%甘油(pH7)。添加 0.01% 硫柳汞作为防腐剂。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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訊號詞
Warning
危險聲明
危險分類
Aquatic Chronic 3 - Skin Sens. 1
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類(WGK)
WGK 2
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Nature communications, 15(1), 4114-4114 (2024-05-16)
Cellular sensitivity to ferroptosis is primarily regulated by mechanisms mediating lipid hydroperoxide detoxification. We show that inositol-requiring enzyme 1 (IRE1α), an endoplasmic reticulum (ER) resident protein critical for the unfolded protein response (UPR), also determines cellular sensitivity to ferroptosis. Cancer
Cell chemical biology, 26(3), 420-432 (2019-01-29)
The initiation and execution of cell death can be regulated by various lipids. How the levels of environmental (exogenous) lipids impact cell death sensitivity is not well understood. We find that exogenous monounsaturated fatty acids (MUFAs) potently inhibit the non-apoptotic
Nature chemical biology, 18(7), 751-761 (2022-06-01)
The selenoprotein glutathione peroxidase 4 (GPX4) prevents ferroptosis by converting lipid peroxides into nontoxic lipid alcohols. GPX4 has emerged as a promising therapeutic target for cancer treatment, but some cancer cells are resistant to ferroptosis triggered by GPX4 inhibition. Using
The EMBO journal, 39(20), e103791-e103791 (2020-09-01)
The link between cholesterol homeostasis and cleavage of the amyloid precursor protein (APP), and how this relationship relates to Alzheimer's disease (AD) pathogenesis, is still unknown. Cellular cholesterol levels are regulated through crosstalk between the plasma membrane (PM), where most
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