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一般說明
APP（淀粉样前体蛋白）基因定位于人染色体 21q21.3。它可编码一种整合膜蛋白。APPα是一种可溶性蛋白质，通过分泌酶γ的α连续裂解而产生。
應用
人分泌型α淀粉样前体蛋白已用于酶联免疫吸附试验 (ELISA)。
生化／生理作用
淀粉样前体蛋白α是一种α分泌酶裂解的可溶性蛋白，具有神经保护特性。它来源于淀粉样前体蛋白。该蛋白质由612个氨基酸组成。几种 G 蛋白偶联受体可激活 αAPP 的分泌酶依赖性加工。它具有神经保护、神经源性和神经营养功能。淀粉样前体蛋白还可刺激基因表达和蛋白质表达。
外觀
0.2 μm 过滤、溶于pH7.4 磷酸盐缓冲盐水的溶液
準備報告
在非变性条件下表达为可溶性蛋白并纯化。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
nwg
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Dementia: New Insights for the Healthcare Professional, 478-478 (2013)
Soluble ?-amyloid Precursor Protein Alpha Binds to p75 Neurotrophin Receptor to Promote Neurite Outgrowth
Noriko Hasebe
PLoS ONE (2013)
Therapeutic Potential of Secreted Amyloid Precursor Protein APPsa
Frontiers in Molecular Neuroscience (2017)
S W Barger et al.
Brain research. Molecular brain research, 40(1), 116-126 (1996-08-01)
A significant fraction of the beta-amyloid precursor protein is proteolytically processed to yield large secreted forms (sAPP). These proteins have pleiotropic effects which potentially involve control of gene expression. We have investigated the influence of sAPP on the class of
C U Pietrzik et al.
Proceedings of the National Academy of Sciences of the United States of America, 95(4), 1770-1775 (1998-03-21)
In various species, thyrotropin (TSH) is known to stimulate both differentiation and proliferation of thyroid follicle cells. This cell type has also been shown to express members of the Alzheimer amyloid precursor (APP) protein family and to release the secretory
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