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About This Item
经验公式（希尔记法）:
C3H8N2O3
CAS号:
分子量:
120.11
MDL號碼:
分類程式碼代碼:
12352209
PubChem物質ID:
NACRES:
NA.26
推荐产品
product name
DL-丝氨酸异羟肟酸酯, seryl-tRNA synthetase inhibitor
品質等級
化驗
≥97% (TLC)
形狀
powder
技術
ligand binding assay: suitable
顏色
white to off-white
應用
cell analysis
儲存溫度
−20°C
SMILES 字串
NC(CO)C(=O)NO
InChI
1S/C3H8N2O3/c4-2(1-6)3(7)5-8/h2,6,8H,1,4H2,(H,5,7)
InChI 密鑰
LELJBJGDDGUFRP-UHFFFAOYSA-N
應用
丝氨酸已被用作丝氨酰-tRNA 合成酶的抑制剂。 DL-丝氨酸异羟肟酸用于通过氨基酸饥饿诱导大肠杆菌中鸟苷 3′-二磷酸5′-二磷酸（ppGpp）的代谢合成。它还用于通过抑制 tRNA 装载来同步大肠杆菌培养物中的细胞周期。
生化／生理作用
丝氨酸参与单碳单位代谢。它与半胱氨酸、神经酰胺、磷脂酰丝氨酸、嘌呤和嘧啶的生物合成有关。在细菌中，它参与色氨酸合成。糖异生是重要的生化过程之一，涉及丝氨酸，尤其在反刍动物中。蛋白质磷酸化是利用丝氨酸的一种此类事件。甘氨酸是丝氨酸的代谢产物，可作为抗氧化剂和神经递质。已知 D-丝氨酸激活脑的 N-甲基-D-天冬氨酸（NMDA）受体。丝氨酸异羟肟酸，一种丝氨酸的结构类似物，它可阻止丝氨酸-tRNA（转移核糖核酸）装载，从而降低大肠杆菌的磷脂和核酸合成。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
G P van Wezel et al.
Microbiology (Reading, England), 141 ( Pt 10), 2519-2528 (1995-10-01)
In Streptomyces coelicolor A3(2), two genes, tuf1 and tuf3, encode the apparent polypeptide chain elongation factors EF-Tu1 and EF-Tu3, respectively. While tuf1 appears to code for the major EF-Tu, the function of tuf3 is unknown. To assess the role of
B Belitsky et al.
The Journal of biological chemistry, 257(9), 4677-4679 (1982-05-10)
Lack of three different amino acids or treatment with the analogue DL-serine hydroxamate does not induce the accumulation of ppGpp and pppGpp, the 3'-pyrophosphates of GDP and GTP, respectively, in Rhizobium meliloti strain 41. Surprisingly, RNA accumulation is controlled under
Yuki Matsumoto et al.
BMC genomics, 14, 808-808 (2013-11-21)
Cell growth rate reflects an organism's physiological state and largely relies on the ability of gene expression to respond to the environment. The relationship between cellular growth rate and gene expression remains unknown. Growth rate-coordinated changes in gene expression were
Yu Zeng et al.
Antimicrobial agents and chemotherapy, 53(11), 4619-4627 (2009-09-02)
The Trojan horse antibiotic albomycin, produced by Streptomyces sp. strain ATCC 700974, contains a thioribosyl nucleoside moiety linked to a hydroxamate siderophore through a serine residue. The seryl nucleoside structure (SB-217452) is a potent inhibitor of seryl-tRNA synthetase (SerRS) in
Effect of serine hydroxamate on phospholipid synthesis in Escherichia coli.
Pizer Ll and Merlie JP
Journal of Bacteriology, 114(3) (1973)
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