S2647

壮观霉素 二盐酸盐 五水合物

powder, γ-irradiated

• 经验公式（希尔记法）: C₁₄H₂₄N₂O₇ · 2HCl · 5H₂O
• CAS号: 22189-32-8
• 分子量: 495.35
• EC號碼: 244-554-3
• MDL號碼: MFCD00150886
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24899532
• NACRES: NA.85

属性

• 生物源: synthetic (inorganic)
• 品質等級: 200
• 等級: for molecular biology
• 無菌: γ-irradiated
• 形狀: powder
• 效力: ≥500 μg per mg
• 儲存條件: (Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.)
• 顏色: white to off-white
• 溶解度: H₂O: soluble at
• 抗生素活性譜: Gram-negative bacteria; Gram-positive bacteria
• 作用方式: protein synthesis | interferes
• 儲存溫度: 2-8°C
• 適合性: nonselective for Escherichia coli; nonselective for coliforms
• SMILES 字串: O.O.O.O.O.Cl.Cl.CN[C@@H]1[C@H](O)[C@H](NC)[C@H]2O[C@]3(O)[C@@H](O[C@H](C)CC3=O)O[C@@H]2[C@H]1O
• InChI: 1S/C14H24N2O7.2ClH.5H2O/c1-5-4-6(17)14(20)13(21-5)22-12-10(19)7(15-2)9(18)8(16-3)11(12)23-14;;;;;;;/h5,7-13,15-16,18-20H,4H2,1-3H3;2*1H;5*1H2/t5-,7-,8+,9+,10+,11-,12-,13+,14+;;;;;;;/m1......./s1
• InChI 密鑰: DCHJOVNPPSBWHK-UXXUFHFZSA-N

说明

一般說明

Chemical structure: aminoglycoside

應用

Spectinomycin is an aminocyclitol antibiotic derived from Streptomyces spectabilis. It has been shown to have a wide variety of uses, including treating acute gonorrheal urethritis and cervictis, to mark cell layers to monitor cell fate during leaf development, as a selection marker in plant related transformation systems for plant cells containing the marker gene Spcr, to study respiratory tract infections of cattle caused by Pasteurella multocida and Mannheimia haemolytica, and to generate plants deficient for the plastid-encoded RNA polymerase on MS-agar media. Spectinomycin also has use in amplification of low copy number plasmid carrying replicons. It is recommended for use in cell culture applications at 7.5-20 mg/L.

生化／生理作用

作用机制：壮观霉素通过与细菌30S核糖体亚基结合并干扰肽基tRNA易位而抑制蛋白质合成和延伸。

抗性机制：rpsE（核糖体蛋白S5的基因）突变可阻止壮观霉素的结合。氨基糖苷-3′-腺苷转移酶基因（aadA）也能使细菌产生抗性。

抗菌谱：壮观霉素能够对抗革兰氏阴性和革兰氏阳性菌。

包裝

100MG

注意

Solutions can be stored at 2-8°C for several weeks or at -20°C for more extended periods.

準備報告

直接在小瓶中用无菌水配制储存液 (10mg/mL)。储存液在 2-8°C 下可保存数周，在 -20°C 下可长期保存。

其他說明

Keep container tightly closed in a dry and well-ventilated place. Keep in a dry place.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H315,H319,H335
• 防範說明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)