跳转至内容
Merck
所有图片(1)

Key Documents

PZ0315

Sigma-Aldrich

芦平曲韦

≥98% (HPLC)

别名:

AG-7088, AG7088, 乙基 (E,4S)-4-[[(2R,5S)-2-[(4-氟苯基)甲基] -6-甲基-5-[(5-甲基-1,2-恶唑-3-羰基)氨基]-4-氧代庚酰基]氨基] -5-[(3S)-2-氧吡咯烷-3-基]戊-2-烯酸酯, 芦平曲韦

登录查看公司和协议定价


About This Item

经验公式(希尔记法):
C31H39FN4O7
分子量:
598.66
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥98% (HPLC)

形狀

powder

光學活性

[α]/D +30 to +40°, c = 0.5 in chloroform-d

顏色

white to beige

溶解度

DMSO: 25 mg/mL, clear

儲存溫度

room temp

InChI

1S/C31H39FN4O7/c1-5-42-27(38)11-10-24(16-21-12-13-33-29(21)39)34-30(40)22(15-20-6-8-23(32)9-7-20)17-26(37)28(18(2)3)35-31(41)25-14-19(4)43-36-25/h6-11,14,18,21-22,24,28H,5,12-13,15-17H2,1-4H3,(H,33,39)(H,34,40)(H,35,41)/b11-10+/t21-,22+,24+,28-/m0/s1

InChI 密鑰

CAYJBRBGZBCZKO-BHGBQCOSSA-N

一般說明

芦平曲韦是一种不可逆的拟肽抑制剂,其可靶向人鼻病毒(HRV)。其之前被命名为AG7088。芦平曲韦也被发现可能涉及 体外 抗病毒活性。

生化/生理作用

芦平曲韦(AG7088)是一种不可逆的人类鼻病毒(HRV)3C蛋白酶抑制剂,其也被发现可以抑制肠病毒和诺如病毒。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ (Lot或Batch)字后找到。

已有该产品?

在文件库中查找您最近购买产品的文档。

访问文档库

S L Binford et al.
Antimicrobial agents and chemotherapy, 49(2), 619-626 (2005-01-28)
The picornavirus 3C protease is required for the majority of proteolytic cleavages that occur during the viral life cycle. Comparisons of published amino acid sequences from 6 human rhinoviruses (HRV) and 20 human enteroviruses (HEV) show considerable variability in the
Jing Wang et al.
Journal of virology, 85(19), 10021-10030 (2011-08-05)
EV71 is the primary pathogenic cause of hand-foot-mouth disease (HFMD), but an effective antiviral drug currently is unavailable. Rupintrivir, an inhibitor against human rhinovirus (HRV), has potent antiviral activities against EV71. We determined the high-resolution crystal structures of the EV71
Daisuke Sano et al.
Food and environmental virology, 13(1), 84-92 (2021-01-05)
This study investigated the influence of viral interference on the detection of enteric viruses using the integrated cell culture (ICC)-PCR with a BGM cell line. It was possible to detect 102 plaque-forming units (PFU)/flask of enterovirus 71 (EV71) in spite
Chunlong Ma et al.
ACS infectious diseases, 6(8), 2260-2270 (2020-07-22)
Enterovirus D68 (EV-D68) is a re-emerging virus that causes moderate to severe respiratory diseases in children. In severe cases, EV-D68 infection can lead to neurological complications called acute flaccid myelitis (AFM). There is currently no antiviral or vaccine available for
Leike Zhang et al.
Virologica Sinica, 35(6), 776-784 (2020-09-11)
The recent outbreak of novel coronavirus pneumonia (COVID-19) caused by a new coronavirus has posed a great threat to public health. Identifying safe and effective antivirals is of urgent demand to cure the huge number of patients. Virus-encoded proteases are

商品

Discover definitions and uses for irreversible inhibitors including the types of irreversible inhibitors: suicide inhibitors, heavy metal inhibitors, and time-dependent inhibitors.

Discover definitions and uses for irreversible inhibitors including the types of irreversible inhibitors: suicide inhibitors, heavy metal inhibitors, and time-dependent inhibitors.

Discover definitions and uses for irreversible inhibitors including the types of irreversible inhibitors: suicide inhibitors, heavy metal inhibitors, and time-dependent inhibitors.

Discover definitions and uses for irreversible inhibitors including the types of irreversible inhibitors: suicide inhibitors, heavy metal inhibitors, and time-dependent inhibitors.

我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门