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生物源
synthetic (organic)
品質等級
化驗
≥98% (HPLC)
形狀
powder
mp
106-108 °C (lit.)
溶解度
ethanol: 50 mg/mL, clear, colorless to light yellow
SMILES 字串
CCCCC1C(=O)N(N(C1=O)c2ccccc2)c3ccccc3
InChI
1S/C19H20N2O2/c1-2-3-14-17-18(22)20(15-10-6-4-7-11-15)21(19(17)23)16-12-8-5-9-13-16/h4-13,17H,2-3,14H2,1H3
InChI 密鑰
VYMDGNCVAMGZFE-UHFFFAOYSA-N
基因資訊
human ... CYP2C9(1559) , PTGIS(5740) , PTGS1(5742) , PTGS2(5743)
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應用
保泰松已被用于：
- 在转基因斑马鱼（LiPan）肝毒素测定中用作肝毒素
- 在高效液相色谱-紫外（HPLC-UV）中用作标准品
- 在鸡′蛋绒毛尿囊膜试验（HET-CAM试验）中用作抗炎化合物
生化／生理作用
保泰松是一种肝毒素，可与血浆蛋白结合。它可用于治疗马的炎症。保泰松具有治疗强直性脊柱炎的潜力。它可通过诱导肌盲样蛋白1（MBNL1）的表达而具有治疗I型强直性肌营养不良（DM1）的潜力。它还有利于骨骼肌中肌肉氯离子通道的表达。
基底
非甾体抗炎化合物；环氧合酶抑制剂，也是环氧合酶过氧化的底物。
訊號詞
Danger
危險分類
Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
其他客户在看
Phenylbutazone induces expression of MBNL1 and suppresses formation of MBNL1-CUG RNA foci in a mouse model of myotonic dystrophy
Chen G, et al.
Scientific Reports, 6, 25317-25317 (2016)
Amit Verma et al.
European journal of medicinal chemistry, 43(5), 897-905 (2007-09-18)
The broad and potent activity of 4-thiazolidinones has established it as one of the biologically important scaffolds. This article is an effort to highlight the importance of the 4-thiazolidinones in the present context and promise they hold for the future.
Phenylbutazone purity challenge
McRae G, et al.
Analytical and Bioanalytical Chemistry, 408(12), 3051-3053 (2016)
HET-CAM bioassay in comparison to the croton oil test for investigating steroidal and non-steroidal compounds
Brandtner AH, et al.
ALTEX, 19(2), 51-56 (2016)
J H Foreman et al.
Equine veterinary journal. Supplement, (38)(38), 601-605 (2011-05-27)
Objective blinded efficacy data during exercise are lacking on the use of single-dose i.v. nonsteroidal anti-inflammatory drugs (NSAIDs) before, during and after exercise. Single i.v. doses of either phenylbutazone (PBZ) or flunixin meglumine (FM) would prove more efficacious than negative
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