推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified from hybridoma cell culture
抗體產品種類
primary antibodies
無性繁殖
3B5H10, monoclonal
形狀
buffered aqueous solution
物種活性
human
包裝
antibody small pack of 25 μL
濃度
~2 mg/mL
技術
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using extract of HEK-293T cells transfected with an N-terminal 171 amino acid fragment of human Huntingtin with a 68 glutamine stretch
同型
IgG1
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
目標翻譯後修改
unmodified
基因資訊
human ... HTT(3064)
一般說明
异常延长的CAG（或CAA）密码子生成超过临界阈值的谷氨酰胺残基重复序列，导致神经退行性疾病。小鼠抗多聚谷氨酰胺单克隆抗体可用于检测多聚谷氨酰胺蛋白表达。适合蛋白质免疫印迹分析。抗多聚谷氨酰胺单克隆抗体特异性识别同聚多聚谷氨酰胺，不受种属影响。
免疫原
GST-human Huntingtin（含有 65Q 的 171 个氨基酸的 N 端片段）。
外觀
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
法律資訊
本品仅供 体外 使用。不得用于商业用途。禁止使用本产品生产用于销售或用于诊断、治疗或药物发现等用途。为了获得将本产品用于商业目的的许可证请联系加利福尼亚大学董事会。本产品在美国专利号 6,291,652许可证下出售，专利归加利福尼亚大学董事会所有。
免責聲明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Xuan Zhang et al.
Cellular and molecular neurobiology, 36(3), 459-470 (2016-03-10)
In Huntington's disease (HD) the imperfect expanded CAG repeat in the first exon of the HTT gene leads to the generation of a polyglutamine (polyQ) protein, which has some neuronal toxicity, potentially mollified by formation of aggregates. Accumulated research, reviewed
Nicholas R Franich et al.
Journal of neuroscience research, 97(12), 1590-1605 (2019-07-10)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into
Veena Prahlad et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14204-14209 (2011-08-17)
The consequence of chronic protein misfolding is the basis of many human diseases. To combat the deleterious effects of accumulated protein damage, all cells possess robust quality-control systems, specifically molecular chaperones and clearance machineries, that sense and respond to protein
Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer.
Wacker JL, Zareie MH
Nature Structural and Molecular Biology, 11(12), 1215-1222 (2001)
Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington's disease.
Christian Landles et al.
PLoS currents, 4, e4fd085bfc9973-e4fd085bfc9973 (2012-08-25)
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