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Merck
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O9637

Sigma-Aldrich

奥沙普秦

solid

别名:

4,5-Diphenyl-2-oxazolepropanoic acid, Daypro

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About This Item

经验公式（希尔记法）:
C18H15NO3
CAS号:
21256-18-8
分子量:
293.32
EC號碼:
244-296-1
MDL號碼:
MFCD00215977
分類程式碼代碼:
12352200
PubChem物質ID:
24278617
NACRES:
NA.77

形狀

solid

品質等級

200

SMILES 字串

OC(=O)CCc1nc(-c2ccccc2)c(o1)-c3ccccc3

InChI

1S/C18H15NO3/c20-16(21)12-11-15-19-17(13-7-3-1-4-8-13)18(22-15)14-9-5-2-6-10-14/h1-10H,11-12H2,(H,20,21)

InChI 密鑰

OFPXSFXSNFPTHF-UHFFFAOYSA-N

基因資訊

human ... PTGIR(5739) , PTGS1(5742) , PTGS2(5743)

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一般說明

Oxaprozin is a non-steroidal anti-inflammatory drug prescribed for rheumatoid arthritis (RA) and osteoarthritis (OA). Oxaprozin binds to albumin. It inhibits arachidonic acid pathway. Oxaprozin has anti-inflammatory property and is an effective inhibitor of cyclooxygenase enzymes, COX-1 and COX-2.

應用

Anti-inflammatory

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Shao-Fa Sun et al.
International journal of biological macromolecules, 39(4-5), 197-200 (2006-07-11)
The interaction between Oxaprozin-E and bovine serum albumin (BSA) was studied by spectroscopic methods including fluorescence and UV-vis absorption spectroscopy. The quenching mechanism of fluorescence of BSA by Oxaprozin-E was discussed to be a dynamic quenching procedure. The number of
Allen Brinker et al.
Drugs & aging, 21(7), 479-484 (2004-05-11)
Data on file with the US FDA, and other published studies, suggest that the selective cyclo-oxygenase (COX)-2 inhibitor NSAID rofecoxib has a greater hypertensive adverse effect than other NSAIDs, including celecoxib. In this study we describe a pharmacoepidemiologic analysis of
Isa M Kara et al.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 68(5), 1018-1024 (2010-03-09)
In this study, oxaprozin, a long-acting nonsteroidal anti-inflammatory drug, and naproxen sodium were compared in terms of their effects on edema, pain, and trismus after surgery for impacted mandibular third molars. Thirty healthy patients with bilaterally impacted mandibular third molars
Recent pharmacodynamic and pharmacokinetic findings on oxaprozin
Rainsford KD, et al.
Inflammopharmacology, 10(3), 185-239 (2002)
Pradip Datta et al.
Therapeutic drug monitoring, 27(3), 305-308 (2005-05-21)
Phenytoin is an anticonvulsant that requires therapeutic drug monitoring. Recently, Bayer HealthCare, Diagnostics Division released a turbidimetric immunoassay of phenytoin on the ADVIA 1650 analyzer. We evaluated the analytic performance of this assay by comparing values obtained in 52 patients
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