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product name
Osteopontin from mouse, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture
生物源
mouse
品質等級
重組細胞
expressed in NSO cells
無菌
sterile
化驗
>95% (SDS-PAGE)
形狀
lyophilized powder
分子量
30 kDa by SDS-PAGE (reducing)
65 kDa by SDS-PAGE (reducing) (doublet)
包裝
pkg of 50 μg
技術
cell culture | mammalian: suitable
雜質
endotoxin, tested
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
mouse ... Spp1(20750)
相关类别
應用
Osteopontin from mouse has been used:
- to study its role in a mouse model of preterm brain injury
- as a positive control to analyze the relationship between the vascular calcification process and osteopontin (OPN) overexpression in the neointima of atherosclerotic plaques
- to study its interaction on the crystal growth process of hydroxyapatite in agarose hydrogels
生化／生理作用
Osteopontin (OPN) is a secreted, highly acidic, calcium binding, phosphorylated glycoprotein that is chemotactic for macrophages, smooth muscle cells, endothelial cells and glial cells. In activated macrophages, OPN inhibits nitric oxide production and cytotoxicity. Human, mouse, rat, pig and bovine OPN share 40% amino acid sequence identity.
外觀
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing 2.5 mg bovine serum albumin.
分析報告
The biological activity is measured by its ability to mediate 293 cell adhesion.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival
Denhardt DT, et al.
The Journal of Clinical Investigation, 107(9), 1055-1061 (2001)
The effect of osteopontin and osteopontin-derived peptides on preterm brain injury
Albertsson AM, et al.
Journal of Neuroinflammation, 11(1), 197-197 (2014)
Osteopontin upregulation in atherogenesis is associated with cellular oxidative stress triggered by the activation of scavenger receptors
Jimenez CAE, et al.
Archives of Medical Research, 43(2), 102-111 (2012)
Effect of osteopontin, chondroitin sulfates (B, C), and human serum albumin on the crystallization behavior of hydroxyapatite in agarose and silica hydrogels
Jimenez CAE, et al.
Crystal Growth & Design, 8(4), 1335-1339 (2008)
Suhail Tahir et al.
Journal of immunology (Baltimore, Md. : 1950), 194(12), 5725-5735 (2015-05-15)
Immune aging results in diminished adaptive immunity and increased risk for autoimmunity. We previously reported a unique PD-1(+) CD44(high)CD4(+) T cell population that increases with age in normal mice. In this study, we indicate that the age-dependent PD-1(+) CD44(high)CD4(+) T
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