N7537

NSC 663284

≥98% (HPLC), solid

• 别名: 6-Chloro-7-(2-morpholin-4-yl-ethylamino)quinoline-5,8-dione
• 经验公式（希尔记法）: C₁₅H₁₆ClN₃O₃
• CAS号: 383907-43-5
• 分子量: 321.76
• MDL號碼: MFCD08276924
• 分類程式碼代碼: 12352200
• PubChem物質ID: 24724556
• NACRES: NA.77

属性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 儲存條件: protect from light
• 顏色: red
• 溶解度: DMSO: ≥10 mg/mL; H₂O: insoluble
• 儲存溫度: 2-8°C
• SMILES 字串: ClC1=C(NCCN2CCOCC2)C(=O)c3ncccc3C1=O
• InChI: 1S/C15H16ClN3O3/c16-11-13(18-4-5-19-6-8-22-9-7-19)15(21)12-10(14(11)20)2-1-3-17-12/h1-3,18H,4-9H2
• InChI 密鑰: BMKPVDQDJQWBPD-UHFFFAOYSA-N
• 基因資訊: human ... CDC25B(994) , DUSP3(1845) , PTPN1(5770)

说明

應用

NSC 663284 has been used as a cell division cycle 25 (CDC25) inhibitor to study its effects on the level of kizuna (kiz) dephosphorylation. It has also been used as a control in horseradish peroxidase/phenol red based assay and resazurin-based redox assay.

生化／生理作用

NSC 663284 is a quinolinediones, which is involved in the inhibition of cell cycle progression at both G1 and G2/M phase. It is also involved in inhibiting the dephosphorylation and activation of cyclin-dependent kinases (Cdks) in vitro and in vivo. NSC 663284 stops the proliferation of various tumor cell lines.

Potent, irreversible, cell permeable and mixed competitive CDC25 phosphatase family inhibitor

安全信息

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: 470.1 °F
• 閃點（°C）: 243.4 °C
• 個人防護裝備: dust mask type N95 (US), Eyeshields, Gloves