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應用
- Genetic determinants of blood pressure and heart rate identified through ENU-induced mutagenesis with automated meiotic mapping.: This study identifies genetic factors affecting blood pressure and heart rate using N-ethyl-N-nitrosourea (ENU)-induced mutagenesis. The research utilizes automated meiotic mapping to reveal the genetic underpinnings of these cardiovascular traits, providing insights that could inform therapeutic targets (Teixeira et al., 2024).
- Clonality, trafficking, and molecular alterations among Hprt mutant T lymphocytes isolated from control mice versus mice treated with N-ethyl-N-nitrosourea.: This study examines the effects of ENU on T lymphocyte clonality and trafficking in mice. The findings provide insights into the mutagenic and immunological impacts of ENU, contributing to our understanding of chemical-induced mutations (Judice et al., 2023).
- Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.: This proof-of-concept study integrates duplex sequencing technology to test genetic toxicity in rats exposed to ENU. The results demonstrate the feasibility and effectiveness of this approach in detecting mutagenic effects, highlighting its potential for genetic toxicity assessment (Smith-Roe et al., 2023).
生化／生理作用
在许多动物种属中具有致癌性的 DNA 烷化剂。诱发多种类型的良性和恶性肿瘤，包括神经组织、胃、食管、胰腺、呼吸道、肠、淋巴网状组织、皮肤和肾脏。
包裝
按干燥品计的重量。
訊號詞
Danger
危險分類
Acute Tox. 3 Oral - Carc. 1B - Repr. 1B
儲存類別代碼
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
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Peng Huang et al.
Journal of genetics and genomics = Yi chuan xue bao, 39(9), 421-433 (2012-10-02)
Zebrafish (Danio rerio) is a well-established vertebrate animal model. A comprehensive collection of reverse genetics tools has been developed for studying gene function in this useful organism. Morpholino is the most widely used reagent to knock down target gene expression
Katherine R Bull et al.
The Journal of pathology, 233(1), 18-26 (2013-12-03)
The study of mutations causing the steroid-resistant nephrotic syndrome in children has greatly advanced our understanding of the kidney filtration barrier. In particular, these genetic variants have illuminated the roles of the podocyte, glomerular basement membrane and endothelial cell in
Georgina Caruana et al.
PloS one, 8(3), e55429-e55429 (2013-03-08)
Mice harbouring gene mutations that cause phenotypic abnormalities during organogenesis are invaluable tools for linking gene function to normal development and human disorders. To generate mouse models harbouring novel alleles that are involved in organogenesis we conducted a phenotype-driven, genome-wide
Jinjun Dang et al.
Blood, 125(23), 3609-3617 (2015-04-10)
Alterations of genes encoding transcriptional regulators of lymphoid development are a hallmark of B-progenitor acute lymphoblastic leukemia (B-ALL) and most commonly involve PAX5, encoding the DNA-binding transcription factor paired-box 5. The majority of PAX5 alterations in ALL are heterozygous, and
Sukalpa Chattopadhyay et al.
Journal of cell communication and signaling, 13(1), 39-52 (2018-07-07)
The evolutionarily conserved Wnt signaling pathway regulates physiological hematopoiesis, a process of formation of blood cells and has been shown to play crucial role in the development of both myeloid and lymphoid malignancies. The Wnt signaling pathway can be broadly
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DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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