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Merck

N5787

Sigma-Aldrich

Anti-Neutrophil Myeloperoxidase antibody produced in rabbit

IgG fraction of antiserum, buffered aqueous solution

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About This Item

MDL號碼:
分類程式碼代碼:
12352203
NACRES:
NA.41

生物源

rabbit

品質等級

共軛

unconjugated

抗體表格

IgG fraction of antiserum

抗體產品種類

primary antibodies

無性繁殖

polyclonal

形狀

buffered aqueous solution

物種活性

human

技術

indirect ELISA: 1:4,000
western blot: 1:4,000

UniProt登錄號

運輸包裝

dry ice

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... MPO(4353)

一般說明

Myeloperoxidase (MPO) is an oxidoreductase which is part of the heme peroxidase superfamily.

免疫原

human neutrophil myeloperoxidase.

應用

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Enzyme-linked immunosorbent assay (1 paper)

生化/生理作用

Myeloperoxidase (MPO) is present in the neutrophils and released when leukocytes are activated. It takes part in defense mechanisms and oxidizes low-density lipoprotein. MPO possesses a chlorinating activity with which it generates hypochlorous acid (an anti-microbial agent). It also decreases the bioavailability of nitric oxide.

外觀

Solution in phosphate buffered saline and 0.05% sodium azide.

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

10 - Combustible liquids

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Judit Kalász et al.
Free radical biology & medicine, 84, 116-127 (2015-03-17)
We set out to characterize the mechanical effects of myeloperoxidase (MPO) in isolated left-ventricular human cardiomyocytes. Oxidative myofilament protein modifications (sulfhydryl (SH)-group oxidation and carbonylation) induced by the peroxidase and chlorinating activities of MPO were additionally identified. The specificity of
Martin T Spang et al.
Nature biomedical engineering, 7(2), 94-109 (2022-12-30)
Decellularized extracellular matrix in the form of patches and locally injected hydrogels has long been used as therapies in animal models of disease. Here we report the safety and feasibility of an intravascularly infused extracellular matrix as a biomaterial for
Matthew J Gounis et al.
Stroke, 45(5), 1474-1477 (2014-04-10)
Noninvasive imaging identifying a predictive biomarker of the bleeding risk of unruptured intracranial aneurysms (UIAs) is needed. We investigated a potential biomarker of UIA instability, myeloperoxidase, in human aneurysm tissue. Human brain aneurysms were harvested after clipping and were histologically
Peng-cheng Xu et al.
BMC immunology, 16, 10-10 (2015-04-17)
C-reactive protein (CRP) exerts prothrombotic effects through dissociating from pentameric CRP (pCRP) into modified or monomeric CRP (mCRP). However, although the high prevalence of venous thromboembolism (VTE) in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has been identified, it
Ishan Agrawal et al.
STAR protocols, 2(3), 100678-100678 (2021-08-07)
Extracellular traps (ETs) are composed of decondensed chromatin and are embedded with various antimicrobial proteins like myeloperoxidase and histones. Recently, we reported that dopamine (DA) induces ETs in BV2 microglia cell line and primary adult human microglia in a manner

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