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Merck
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N2540

Sigma-Aldrich

NS5806

≥98% (HPLC)

别名:

N-[3,5-bis(trifluoromethyl)phenyl]-N′-[2,4-dibromo-6-(1H-tetrazol-5-yl)phenyl]-urea

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About This Item

经验公式（希尔记法）:
C16H8Br2F6N6O
CAS号:
426834-69-7
分子量:
574.07
MDL编号:
MFCD18432708
UNSPSC代码:
12352200
PubChem化学物质编号:
329818416
NACRES:
NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to faint yellow

溶解性

DMSO: >30 mg/mL

储存温度

2-8°C

SMILES字符串

FC(F)(F)c1cc(NC(=O)Nc2c(Br)cc(Br)cc2-c3nnn[nH]3)cc(c1)C(F)(F)F

InChI

1S/C16H8Br2F6N6O/c17-8-4-10(13-27-29-30-28-13)12(11(18)5-8)26-14(31)25-9-2-6(15(19,20)21)1-7(3-9)16(22,23)24/h1-5H,(H2,25,26,31)(H,27,28,29,30)

InChI key

UZWJWROOLOOCPQ-UHFFFAOYSA-N

相关类别

生化/生理作用

NS5806 increases peak current amplitude of the potassium channel Kv4.3 (EC50 = 5.3 uM). NS5806 also slows Kv4.3 and Kv4.2 current dacay in channel complexes containing KChIP2. In ventricular cardiomycytes, NS5806 increases transient outward current and reproduces the electrocardiographic profile of Brugada syndrome.
NS5806 is an activator or transient outward potassium current (Ito).

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H413

危险分类

Acute Tox. 3 Oral - Aquatic Chronic 4

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000345074
0000345075
0000345074
0000345075
0000329366

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Sufen Wang et al.
Frontiers in physiology, 10, 1509-1509 (2020-01-11)
Background: NS5806 activates the transient outward potassium current Ito, and has been claimed to reproduce Brugada Syndrome (BrS) in ventricular wedge preparations. Ito modulates excitation-contraction coupling, which is critical in alternans dynamics. We explored NS5806-arrhythmogenic effects in the intact whole
José M Di Diego et al.
PloS one, 15(11), e0242747-e0242747 (2020-11-25)
J wave syndromes (JWS), including Brugada (BrS) and early repolarization syndromes (ERS), are associated with increased risk for life-threatening ventricular arrhythmias. Pharmacologic approaches to therapy are currently very limited. Here, we evaluate the effects of the natural flavone acacetin. The
Jinjing Yao et al.
Cell reports, 32(12), 108169-108169 (2020-09-24)
Neuronal hyperactivity is an early primary dysfunction in Alzheimer's disease (AD) in humans and animal models, but effective neuronal hyperactivity-directed anti-AD therapeutic agents are lacking. Here we define a previously unknown mode of ryanodine receptor 2 (RyR2) control of neuronal

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