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MAK112

Sigma-Aldrich

精氨酸酶活性检测试剂盒

sufficient for 200 colorimetric tests

别名:

精氨酸酶检测试剂盒

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About This Item

UNSPSC代码:
12161503
NACRES:
NA.84

用途

sufficient for 200 colorimetric tests

检测方法

colorimetric

相关疾病

cancer; immunological diseases; gastrointestinal diseases

储存温度

−20°C

基因信息

human ... ARG1(383) , ARG2(384)
mouse ... ARG1(11846) , ARG2(11847)
rat ... ARG2(29215) , Arg1(29221)

相关类别

一般描述

精氨酸酶是一种含锰酶，可催化精氨酸转化为尿素和鸟氨酸。大多数哺乳动物体内存在两种同种型精氨酸酶，其组织分布和亚细胞定位有所不同。精氨酸酶I是一种胞质蛋白，主要在肝脏中表达，在肝脏中催化尿素循环的第五步和最后一步。精氨酸酶II是一种线粒体蛋白，组织分布更广，其功能可包括一氧化氮和多胺代谢。精氨酸酶I的活性或表达降低可导致常染色体隐性遗传病高精氨酸血症。血清精氨酸酶活性增加与肝损伤和某些病理状态（如癌症）有关。精氨酸酶还参与免疫系统的多种炎症反应，例如巨噬细胞介导的细胞毒性。

应用

精氨酸酶活性检测试剂盒用于评估精氨酸酶的活性。

特点和优势

兼容高通量的操作系统。

适用性

该试剂盒适用于检测酶制备体系、血清、血浆、组织培养物及类似样品中的精氨酸酶活性。还可用于研究药物对精氨酸酶活性的影响。

原理

在该检测中，精氨酸酶可催化精氨酸转化成尿素和鸟氨酸。产生的尿素与底物特异性反应，产生与存在的精氨酸酶活性成比例的有色产物。

象形图

Health hazardCorrosion
GHS08,GHS05

警示用语：

Danger

危险分类

Aquatic Chronic 3 - Eye Dam. 1 - Met. Corr. 1 - Repr. 1B - Skin Corr. 1A

储存分类代码

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
112CE06A26
112CE06A19
112CE06A26
112CE06A19
112CD10A10

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氨检测试剂盒 sufficient for 200 fluorometric tests

Sigma-Aldrich

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氨检测试剂盒

Razieh Tavakoli Oliaee et al.
Microbial pathogenesis, 126, 368-378 (2018-11-07)
Detection of the mechanism of host/parasite interactions in unresponsive forms of anthroponotic cutaneous leishmaniasis (ACL) caused by Leishmania tropica is helpful for immunotherapy and vaccine development. In the present study, the gene expression of toll-like receptors (TLRs), TNF-α, iNOS and
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency.
Martina H.
Journal of inherited metabolic disease, 39(3), 331?340-331?340 (2016)
Arginase activity, urea, and hydroxyproline concentration are reduced in keratoconus keratocytes.
Stachon T, et al.
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Anti-apoptotic role of spermine against lead and/or gamma irradiation-induced hepatotoxicity in male rats.
Rasha A K, et al.
Environmental Science and Pollution Research International, 24(31), 24272-24283 (2017)
Monica Vaccari et al.
Frontiers in immunology, 10, 1072-1072 (2019-05-30)
Vaccination with DNA-SIV + ALVAC-SIV + gp120 alum results in inflammasome activation, high levels of IL-1β production, emergency myelopoiesis, and the egress of CXCR4+ CD14+ pre-monocytes from bone marrow. Previously we have shown that this vaccine-induced innate monocyte memory is
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