This product is stored at -20°C and is not assigned an expiration or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, please access the Product Dating Information document under ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/US/en/life-science/quality-and-regulatory-management/quality-services.
M7571
MK-571 钠盐 水合物
MK-571 sodium salt hydrate
≥95% (HPLC), powder, leukotriene D4 antagonist
别名:
5-（3-（2-（7-氯喹啉-2-基）乙烯基）苯基）-8-二甲基氨基甲酰-4,6-二硫杂辛酸 钠盐 水合物, L-660711
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所有图片(3)
About This Item
经验公式（希尔记法）:
C26H26ClN2NaO3S2 · xH2O
CAS号:
分子量:
537.07 (anhydrous basis)
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
价格与库存信息目前不能提供
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产品名称
MK-571 钠盐 水合物, ≥95% (HPLC)
质量水平
方案
≥95% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 15 mg/mL, clear
创始人
Merck & Co., Inc., Kenilworth, NJ, U.S.
运输
wet ice
储存温度
−20°C
SMILES字符串
O.[Na+].CN(C)C(=O)CCSC(SCCC([O-])=O)c1cccc(\C=C\c2ccc3ccc(Cl)cc3n2)c1
InChI
1S/C26H27ClN2O3S2.Na.H2O/c1-29(2)24(30)12-14-33-26(34-15-13-25(31)32)20-5-3-4-18(16-20)6-10-22-11-8-19-7-9-21(27)17-23(19)28-22;;/h3-11,16-17,26H,12-15H2,1-2H3,(H,31,32);;1H2/q;+1;/p-1/b10-6+;;
InChI key
MSHRPLRGSQECLY-DOLBFOAYSA-M
应用
生化/生理作用
MK 571 是一种强效选择性白三烯 D4 (LTD4) 拮抗剂和 ABCC 多药耐药蛋白 1 (MRP1) 抑制剂。半胱氨酰白三烯 (CysLTs)，LTC4、LTD4 和 LTE4 通过两种不同的 G 蛋白偶联受体介导其作用。LTD4 是 CysLT1 受体的首选配体，而 LTC4 和 LTD4 与 CysLT2 受体的亲和力大致相等。MK 571 是一种选择性、口服活性 CysLT1 受体拮抗剂。阻断 LTD4 而非 LTC4 与人和豚鼠肺膜的结合，Ki 值分别为 0.22 nM 和 2.1 nM。MK 571 可有效阻断重组人和小鼠 CysLT1 受体的 LTD4 活化，但对阻断重组人或鼠 CysLT2 受体的 LTC4 或 LTD4 活化无效。它可能抑制 MRP1，并已显示克服获得性砷耐受性。
MK-571 是一种强效选择性白三烯 D4 (LTD4) 拮抗剂和 ABCC 多药耐药蛋白 1 (MRP1) 抑制剂。
特点和优势
该化合物是由Merck & Co., Inc., Kenilworth, NJ, U.S.开发的。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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商品
We offer many products related to leukotriene receptors for your research needs.
We offer many products related to leukotriene receptors for your research needs.
We offer many products related to leukotriene receptors for your research needs.
We offer many products related to leukotriene receptors for your research needs.
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I have a question regarding storage of MK-571 sodium salt hydrate. For how long the powder form can be stored at -20C? Thanks in advance.
1 answer-
Helpful?
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Does MK-571 sodium salt hydrate has to be prepared freshly before experiments or can it be diluted and stored as a stock solution; without affecting the stability? Thanks in advance
1 answer-
Solution stability studies have not been performed on this compound. However, other sources report that the material is stable up tp 6 months when stored in aliquots at -20°C.
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