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生物源
synthetic
形狀
powder
儲存溫度
room temp
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一般說明
Lipodisq®试剂是来源于苯乙烯和马来酸的新型聚合物。Lipodisq®聚合物能够形成可在膜蛋白中结合的纳米脂质盘状颗粒。在pH 7.4下,Lipodisqs的直径通常为9-10 纳米。
應用
Lipodisq®试剂是来源于苯乙烯和马来酸的新型聚合物。 Lipodisq聚合物能够形成可在膜蛋白中结合的纳米脂质盘状颗粒。Lipodisq技术可以在不使用表面活性剂的情况下溶解常用的脂质,例如二肉豆蔻酰磷脂酰胆碱(DMPC)。通常,lipodisq聚合物有望用于减少膜蛋白增溶用洗涤剂的使用。在pH 7.4下,Lipodisqs的直径通常为9-10 纳米。
Lipodisq技术可以在不使用表面活性剂的情况下溶解常用的脂质,例如二肉豆蔻酰磷脂酰胆碱(DMPC)。
功能pH范围: 6.0 - 9.0
功能pH范围: 6.0 - 9.0
生化/生理作用
Lipodisq®聚合物有望用于减少膜蛋白增溶用清洁剂的使用。以足量碱(如KOH、NaOH)将本品溶解在水性溶液中,会导致每个酸酐基团水解成两个羧酸/羧酸酯基团。这种作用使SMA可以在水性介质中溶解。Lipodisq® 是一种潜在的膜模拟系统。
法律資訊
Lipodisq is a registered trademark of Malvern Cosmeceutics Limited
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
Detergent-free incorporation of a seven-transmembrane receptor protein into nanosized bilayer Lipodisq particles for functional and biophysical studies
Nano Letters, 12(9), 4687-4692 (2012)
Nano letters, 12(9), 4687-4692 (2012-07-26)
SMA-Lipodisq nanoparticles, with one bacteriorhodopsin (bR) per 12 nm particle on average (protein/lipid molar ratio, 1:172), were prepared without the use of detergents. Using pulsed and continuous wave nitroxide spin label electron paramagnetic resonance, the structural and dynamic integrity of
Biochemistry, 52(35), 5967-5984 (2013-08-22)
Electron paramagnetic resonance (EPR) spectroscopy is a very powerful biophysical tool that can provide valuable structural and dynamic information about a wide variety of biological systems. The intent of this review is to provide a general overview for biochemists and
Characterizing the structure of lipodisq nanoparticles for membrane protein spectroscopic studies
Biochimica et Biophysica Acta - Biomembranes, 1848(1), 329-333 (2015)
Chemistry and physics of lipids, 222, 51-58 (2019-05-19)
Lipodisq™ nanoparticles have been used to extract surface lipids from the cuticle of two strains (wild type, N2 and the bacteria-resistant strain, agmo-1) of the C. elegans nematode without loss of viability. The extracted lipids were characterized by thin layer
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