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Merck
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主要文件

L5024

Sigma-Aldrich

脂多糖 来源于大肠杆菌 0127:B8

purified by ion-exchange chromatography, TLR ligand tested

别名:

LPS

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About This Item

EC號碼:
297-473-0
MDL號碼:
MFCD00212998
分類程式碼代碼:
12352201
NACRES:
NA.25

生物源

Escherichia coli (O127:B8)

品質等級

200

形狀

lyophilized powder

純化經由

ion-exchange chromatography

雜質

<1% Protein
<1% RNA

顏色

white to yellow cast

溶解度

water: soluble

運輸包裝

ambient

儲存溫度

2-8°C

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相关类别

一般說明

该产物从大肠杆菌血清型 O127：B8 中提取，并通过离子交换纯化。源菌株为 ATCC 12740。该 LPS 血清型已经用于脓毒性休克的研究，并且可在大鼠肾小球 masangial 细胞中诱导小鼠巨噬细胞和 PAF 中的 NOS 合成。

應用

脂多糖（LPS）是革兰氏阴性菌细胞壁的特征组分。LPS及其脂质A部分可通过能够识别常见的病原体相关分子模式（PAMP）的Toll样受体蛋白家族成员Toll样受体4（TLR4）刺激先天性免疫系统细胞。

生化／生理作用

脂多糖（LPS）位于膜的外层，并且在非包封的菌株中暴露在细胞表面上。它们有助于外膜的完整性，并保护细胞免受胆汁盐和亲脂性抗生素的作用。

準備報告

产物可溶于水（5 mg/mL）或细胞培养基（1 mg/mL），产生浑浊的淡黄色溶液。在经过涡旋，并升温至 70-80°C 后，含水盐水变得更浓缩，但仍然浑浊（20mg/mL）。脂多糖分子在每种溶剂中均形成胶束。在水和磷酸盐缓冲盐水中观察到浑浊的溶液。使用有机溶剂，溶液也是浑浊的。甲醇产生具有漂浮物的浑浊悬浮液，而水则产生均匀浑浊的溶液。

其他說明

为了全面了解我们针对客户研究提供的各种脂多糖产品，建议您访问我们的碳水化合物分类页面。

象形圖

Skull and crossbones
GHS06

訊號詞

Danger

危險聲明

H300

危險分類

Acute Tox. 2 Oral

儲存類別代碼

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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Mingju Cao et al.
Frontiers in cellular neuroscience, 9, 294-294 (2015-08-25)
Neuroinflammation in utero may result in life-long neurological disabilities. The molecular mechanisms whereby microglia contribute to this response remain incompletely understood. Lipopolysaccharide (LPS) or saline were administered intravenously to non-anesthetized chronically instrumented near-term fetal sheep to model fetal inflammation in
M Cortes et al.
Scientific reports, 7(1), 10645-10645 (2017-09-08)
Neuroinflammation in utero may result in life-long neurological disabilities. Microglia play a pivotal role, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of microglia. We hypothesized that agonism on α7 nicotinic acetylcholine
Kristen R Hollinger et al.
Journal of Alzheimer's disease : JAD, 77(1), 437-447 (2020-07-18)
Given the emergent aging population, the identification of effective treatments for Alzheimer's disease (AD) is critical. We investigated the therapeutic efficacy of JHU-083, a brain-penetrable glutamine antagonist, in treating AD using the humanized APOE4 knock-in mouse model. Cell culture studies
Mingju Cao et al.
Frontiers in immunology, 10, 1063-1063 (2019-05-31)
Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on
Manman Geng et al.
Clinical immunology (Orlando, Fla.), 220, 108579-108579 (2020-09-01)
Endoplasmic reticulum (ER) stress associated proteins contribute to the pathogenesis of rheumatoid arthritis (RA) through affecting synoviocyte proliferation and proinflammatory cytokine production. The role of DERL3, an ER-associated degradation component, in joint inflammation of RA was explored. Synovial tissues from
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