所有图片(1)
About This Item
经验公式（希尔记法）:
C18H18ClN3O · C4H6O4
CAS号:
分子量:
445.90
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
价格与库存信息目前不能提供
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表单
solid
质量水平
颜色
white
溶解性
H2O: soluble
创始人
Watson
SMILES字符串
CN(CC1)CCN1C2=NC3=C(C=CC=C3)OC4=C2C=C(Cl)C=C4.OC(CCC(O)=O)=O
InChI
1S/C18H18ClN3O.C4H6O4/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18;5-3(6)1-2-4(7)8/h2-7,12H,8-11H2,1H3;1-2H2,(H,5,6)(H,7,8)
InChI key
YQZBAXDVDZTKEQ-UHFFFAOYSA-N
基因信息
human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR7(3363)
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生化/生理作用
D2/D4 dopamine receptor antagonist; 5-HT2A/2B, 5-H7 serotonin receptor antagonist; dibenzoxazepine antipsychotic agent.
特点和优势
This compound was developed by Watson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
其他客户在看
B L Roth et al.
Psychopharmacology, 120(3), 365-368 (1995-08-01)
The affinities of 13 atypical and 12 typical antipsychotic drugs for the cloned rat D4 dopamine receptor and the D4/D2 ratios were examined. Of the atypical antipsychotic drugs tested, only clozapine, risperidone, olanzapine, zotepine and tiospirone had affinities less than
Robert H Howland
Journal of psychosocial nursing and mental health services, 50(1), 16-18 (2012-01-11)
Acute agitation in patients with schizophrenia or bipolar disorder is an important clinical management problem. Liquid concentrates, orally disintegrating tablets, and/or intramuscular formulations of several second-generation atypical antipsychotic drugs are available for treating acute agitation. Loxapine is an older first-generation
[Progress through formulation].
Heike Oberpichler-Schwenk
Medizinische Monatsschrift fur Pharmazeuten, 36(7), 243-243 (2013-08-01)
E Glusa et al.
British journal of pharmacology, 130(3), 692-698 (2000-05-24)
The endothelial 5-HT receptor mediating relaxation of pig pulmonary artery has been characterized using the selective 5-HT(2B) receptor agonist BW 723C86 and a variety of structurally diverse 5-HT receptor antagonists. If arterial rings with intact endothelium were precontracted with prostaglandin
R T Owen
Drugs of today (Barcelona, Spain : 1998), 49(3), 195-201 (2013-03-26)
The treatment of acute agitation in psychiatric patients has traditionally involved the use of oral or intramuscular benzodiazepines, antipsychotics or their combination. However, oral medication may have too slow an onset and while the intramuscular route is faster, it carries
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