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形狀
buffered aqueous solution
品質等級
比活性
≥5 units/mg protein
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−20°C
基因資訊
human ... KLK1(3816)
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一般說明
Kallikrein肽酶属于15个高度保守的胰蛋白酶或胰凝乳蛋白酶家庭的成员。血浆激肽释放酶（PK）是一种来源于血浆前激肽释放酶的丝氨酸蛋白酶，也是一种在血液循环中含量较高的酶原。KLKB1基因位于人染色体4q35.2上。
應用
从人血浆中提取的激肽释放酶已用于：
- 培养人肝癌细胞系
- 研究其对来自脑膜炎奈瑟氏菌的奈瑟球菌肝素结合抗原（NHBA）的裂解作用
- 肽酶抑制分析
生化／生理作用
血浆激肽释放酶（PK）参与缓激肽的合成，可维持血液代谢物水平和高血压。它还参与凝血因子XII的激活，促进炎症和内源性凝血途径。PK控制心血管系统中的蛋白水解级联反应，如激肽酶激肽系统、肾素血管紧张素系统、纤维蛋白溶解系统和补体旁路等。它参与胰高血糖素样肽-1（GLP-1）和神经肽Y（NPY） 的裂解，这表明血浆激肽释放酶可能会影响代谢和糖尿病。
單位定義
一个酶活性单位是指在pH 8.7、25°C条件下，每分钟将1.0 μMNα-苯甲酰基-L-精氨酸乙酯（BAEE）水解为Nα-苯甲酰基-L-精氨酸和乙醇所需的酶量。
外觀
溶于20 mM Tris-HCl (pH 7.8)和100 mM NaCl的溶液中。
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
其他客户在看
Xueqing Xu et al.
Nucleic acids research, 37(22), 7381-7393 (2009-10-13)
A subtelomeric region, 4q35.2, is implicated in facioscapulohumeral muscular dystrophy (FSHD), a dominant disease thought to involve local pathogenic changes in chromatin. FSHD patients have too few copies of a tandem 3.3-kb repeat (D4Z4) at 4q35.2. No phenotype is associated
Elisa Pantano et al.
PloS one, 14(8), e0203234-e0203234 (2019-08-02)
Neisserial Heparin Binding Antigen (NHBA) is a surface-exposed lipoprotein of Neisseria meningitidis and a component of the Bexsero vaccine. NHBA is characterized by the presence of a highly conserved Arg-rich region involved in binding to heparin and heparan sulphate proteoglycans
R Dellalibera-Joviliano et al.
Scandinavian journal of immunology, 72(2), 128-133 (2010-07-14)
Some components of the kinin system such as plasma kallikrein levels, the activities of tissue kallikrein (including saliva) and kininase II and the concentrations of kininogen fractions (low-molecular weight/LKg and high-molecular weight/HKg) were evaluated in the plasma of patients with
Allen Clermont et al.
Diabetes, 60(5), 1590-1598 (2011-03-30)
Plasma kallikrein (PK) has been identified in vitreous fluid obtained from individuals with diabetic retinopathy and has been implicated in contributing to retinal vascular dysfunction. In this report, we examined the effects of PK on retinal vascular functions and thickness
H Austin et al.
Journal of thrombosis and haemostasis : JTH, 9(3), 489-495 (2011-01-15)
We evaluated 10 single-nucleotide polymorphisms (SNPs) identified in three European case-control studies as risk factors for venous thrombosis. We sought to replicate the positive findings from this report among Whites and to evaluate the association of these SNPs with venous
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