推荐产品
生物源
rat
品質等級
重組細胞
expressed in bacteria
化驗
≥95%
形狀
lyophilized powder
分子量
~19 kDa
包裝
pkg of 1 vial
濃度
300,000-800,000,000 units/mL
技術
cell culture | mammalian: suitable
UniProt登錄號
運輸包裝
dry ice
儲存溫度
−70°C
基因資訊
rat ... Ifna_mapped(24480)
一般說明
Interferon α is a cytokine, that belongs to type I interferon (IFNs) family. It possesses 14 genes, including 2 pseudo-genes or allelic forms that encodes for 13 proteins. It is mainly induced in response to viral infection. It is a non-leukemogenic peptide.
生化／生理作用
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.
Interferon α play a key role in the inhibition of in vitro proliferation of hematopoietic progenitors. It mediates the regulation of gene expression that is responsible for development and functionality of innate and adaptive immunity. It has been used as myelosuppressive agent for myeloproliferative neoplasms (MPNs).
外觀
Lyophilized from a solution containing citric acid buffered saline (CBS pH 5.0) and 125 mM trehalose
分析報告
The biological activity is determined in the cytopathic effect inhibition assay using rat epithelial-like (RATEC) cells with vesicular stomatitis virus (VSV) in the presence of 2mM glutathione. The cytopathic effect of 50% is produced with ~1 unit/mL interferon. Since there is no international rat interferon α standard, units are determined with respect to the NIH international standard reference for mouse interferon α/β.
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Agnieszka Rynda et al.
PloS one, 5(1), e8720-e8720 (2010-01-22)
Conventional methods to induce tolerance in humans have met with limited success. Hence, efforts to redirect tolerogen uptake using reovirus adhesin, protein sigma 1 (psigma1), may circumvent these shortcomings based upon the recent finding that when reovirus psigma1 is engineered
The interferon system of teleost fish
Robertsen B
Fish & Shellfish Immunology, 20(2), 172-191 (2006)
Jie-Hyun Kim et al.
Yonsei medical journal, 47(6), 793-798 (2006-12-28)
Combination therapy with interferon alpha (IFN-alpha) and ribavirin for 24 or 48 weeks according to HCV genotype has improved the overall sustained virological response (SVR) rates to approximately 40%. The aim of this study was to investigate the long-term efficacy
Type I interferons (?/?) in immunity and autoimmunity
Theofilopoulos AN, et al.
Fish & Shellfish Immunology, 23(11), 307-335 (2005)
Interferon- ? therapy in bcr-abl-negative myeloproliferative neoplasms
Kiladjian JJ, et al.
Leukemia, 22(11), 1990-1990 (2008)
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