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Merck
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Key Documents

I4028

Sigma-Aldrich

Monoclonal Anti-Interleukin-18 Receptor antibody produced in mouse

clone 70625.111, purified immunoglobulin, lyophilized powder

别名:

Anti-IL-18 Receptor

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About This Item

MDL號碼:
分類程式碼代碼:
51111800
NACRES:
NA.41

生物源

mouse

品質等級

共軛

unconjugated

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

70625.111, monoclonal

形狀

lyophilized powder

物種活性

human

技術

flow cytometry: suitable (2.5μg/SUP>106 cell)
immunocytochemistry: 8-25 μg/mL
immunohistochemistry: 8-25 μg/mL

同型

IgG1

UniProt登錄號

儲存溫度

−20°C

目標翻譯後修改

unmodified

基因資訊

human ... IL18R1(8809)

一般說明

The antibody will neutralize the biological activity of recombinant human IL-18 receptor.

免疫原

recombinant human IL-18 receptor extracellular domain, expressed in NS0 cells.

生化/生理作用

IL-18 belongs to the IL-1 cytokine superfamily and is a regulator of innate and acquired immune responses. The immune responses of IL-18 are mediated by its interaction and subsequent signaling by IL-18 receptor complex. The IL-18R complex is made up of α chain that binds to extracellular IL-18 and a β chain that is involved in signal transduction. The IL-18/IL-18R signaling enhances T and NK cell maturation, cytotoxicity and secretion of cytokines.

外觀

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

準備報告

Purified using protein G.

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儲存類別代碼

13 - Non Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Diana Boraschi et al.
European cytokine network, 17(4), 224-252 (2007-03-14)
IL-18 is among the cytokines responsible for immune-mediated pathologies and is probably one of the factors that contribute to the pathogenesis of autoimmune diseases. Identification of the causes of uncontrolled IL-18 production and activity in autoimmunity would allow for novel
J Alastair Gracie et al.
Journal of leukocyte biology, 73(2), 213-224 (2003-01-30)
Interleukin-18 (IL-18), a recently described member of the IL-1 cytokine superfamily, is now recognized as an important regulator of innate and acquired immune responses. IL-18 is expressed at sites of chronic inflammation, in autoimmune diseases, in a variety of cancers

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