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Merck

H0500

Sigma-Aldrich

1,2,3,4-四氢哈尔满-3-羧酸

别名:

1-甲基-1,2,3,4-四氢-β-咔啉-3-羧酸

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About This Item

经验公式(希尔记法):
C13H14N2O2
CAS号:
分子量:
230.26
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

儲存溫度

−20°C

品質等級

SMILES 字串

CC1NC(Cc2c1[nH]c3ccccc23)C(O)=O

InChI

1S/C13H14N2O2/c1-7-12-9(6-11(14-7)13(16)17)8-4-2-3-5-10(8)15-12/h2-5,7,11,14-15H,6H2,1H3,(H,16,17)

InChI 密鑰

ZUPHXNBLQCSEIA-UHFFFAOYSA-N

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應用

Reactant involved in synthesis of molecules for biological studies including:
  • Cytotoxicity and insecticidal activities of harmine derivatives
  • Isoquinolines, β-carbolines, and 3-deazapurines via oxidative decarboxylation
  • Cytotoxic evaluation of 1,3-di- and 1,3,9-trisubstituted β-carbolines

生化/生理作用

在与 L-色氨酸摄取相关的嗜酸性粒细胞增多-肌痛综合征中存在牵连。

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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Analysis of L-tryptophan for the etiology of eosinophilia-myalgia syndrome.
MMWR. Morbidity and mortality weekly report, 39(34), 589-591 (1990-08-31)
S Fukushima et al.
Alcohol (Fayetteville, N.Y.), 9(1), 31-35 (1992-01-01)
We conducted analyses of 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (1Me3C-THBC) by gas chromatography-mass spectrometry (negative chemical ionization mode) to investigate its presence and the in vivo condensation between tryptophan and AcH. 1Me3C-THBC was found in the cerebellum and the cerebrum of normal rat
J Adachi et al.
Archives of toxicology, 67(4), 284-289 (1993-01-01)
Peak E substance, 1,1'-ethylidenebis[tryptophan], a contaminant found in L-tryptophan tablets, has been suggested as a causative agent for eosinophilia-myalgia syndrome (EMS). Peak E substance (50 mg/kg) was administered perorally to Wistar rats to determine its metabolism and distribution. A purification
A comparative study of tissue distribution and excretion among three substances implicated in eosinophilia-myalgia syndrome.
J Adachi et al.
Advances in experimental medicine and biology, 398, 365-370 (1996-01-01)
H Tsuchiya et al.
Journal of pharmaceutical sciences, 83(3), 415-418 (1994-03-01)
A high-performance liquid chromatographic method was developed to quantify 1,2,3,4-tetrahydro-beta-carboline (TBC) and 1-methyl-1,2,3,4-tetrahydro-beta-carboline (MTBC) in human urine. Urine samples with added internal standard were subjected to a reaction with fluorescamine and solvent extractions to remove the precursor tryptamine, which readily

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