推荐产品
方案
97%
表单
solid
mp
121-123 °C (lit.)
官能团
amine
SMILES字符串
COc1ccc2[nH]cc(CCN)c2c1
InChI
1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
InChI key
JTEJPPKMYBDEMY-UHFFFAOYSA-N
基因信息
human ... HTR1A(3350) , HTR2A(3356) , HTR2C(3358)
rat ... Htr2a(29595) , Htr2c(25187) , Htr7(65032)
正在寻找类似产品? 访问 产品对比指南
一般描述
5-甲氧色胺（一种褪黑素的代谢物）在人角质细胞中应对紫外B（UVB）的保护性作用已得到研究。
应用
5-甲氧基色胺作为一种激动剂已被用于5-羟色胺1受体的药理作用研究中。
用于制备以下物质的反应物：
- shishijimicin A的咔啉二糖结构域
- 褪黑激素类似物用于降低眼压
- 5-HT4受体配体
- 分选酶A和异柠檬酸裂解酶的抑制剂
- 用于治疗缺血/再灌注（I/R）损伤的治疗剂
- Aurora和表皮生长因子受体激酶抑制剂
- 用于治疗人乳头瘤病毒感染的药剂
- Manzamine类似物用于控制神经炎症和脑部感染
- 促炎细胞因子的抑制剂
- Tacrine-melatonin杂合物作为阿尔茨海默病的多功能药物
包装
无底玻璃瓶。内含物在插入的融合锥体内。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Hyun-Ji Kim et al.
Combinatorial chemistry & high throughput screening, 11(4), 316-324 (2008-05-14)
Continuous identification and validation of novel drug targets require the development of rapid, reliable, and sensitive cell-based high-throughput screening (HTS) methods for proposed targets. Recently, the 5-HT(6) receptor (5-HT(6)R), a member of the class of recently discovered 5-HT receptors, has
Jeff DeFalco et al.
Bioorganic & medicinal chemistry letters, 20(23), 7076-7079 (2010-10-23)
5-Benzyloxytryptamine 19 was found to act as an antagonist of the TRPM8 ion-channel. For example, 19 had an IC(50) of 0.34 μM when menthol was used as the stimulating agonist. Related commercially-available tryptamine derivatives showed diminished, or no antagonist activity
John M Corkery et al.
Progress in neuro-psychopharmacology & biological psychiatry, 39(2), 259-262 (2012-06-12)
5-MeO-DALT (N,N-diallyl-5-methoxytryptamine) is a psychoactive substance, sold primarily over the Internet as a 'research chemical' or 'plant food'. Although details for the synthesis of this tryptamine have been available since 2004, its use as a hallucinogenic drug has been reported
Anna Haduch et al.
Pharmacological research, 67(1), 53-59 (2012-10-27)
Brain serotonin has been implicated in the pathophysiology of a wide spectrum of psychiatric disorders, as well as in the mechanism of action of psychotropic drugs. The aim of present study was to identify rat cytochrome P450 (CYP) isoforms which
Amir Hanna-Elias et al.
European journal of medicinal chemistry, 44(7), 2952-2959 (2009-02-19)
Twenty-three indole-3-methanamines were designed, synthesized and evaluated as ligands for the 5-HT(4) receptor. Compounds I-d, I-j, I-o, I-q and I-u showed good affinity at 100 microM and I-o was found to be only 5-fold less potent than the agonists serotonin
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门