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About This Item
经验公式（希尔记法）:
C11H13N3O5 · HCl
CAS号:
分子量:
303.70
EC號碼:
MDL號碼:
分類程式碼代碼:
12352204
PubChem物質ID:
NACRES:
NA.83
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化驗
≥98% (HPLC)
形狀
powder
溶解度
water: 5 mg/mL, clear, yellow
儲存溫度
2-8°C
SMILES 字串
Cl.NC(CCC(=O)Nc1ccc(cc1)N(=O)=O)C(O)=O
InChI
1S/C11H13N3O5.ClH/c12-9(11(16)17)5-6-10(15)13-7-1-3-8(4-2-7)14(18)19;/h1-4,9H,5-6,12H2,(H,13,15)(H,16,17);1H
InChI 密鑰
OJEVFSFTVARWQX-UHFFFAOYSA-N
應用
L-谷氨酸 γ-（对硝基苯胺）盐酸盐已用作溶质载体家族 1 成员 5（SLC1A5）抑制剂：
- 或细胞膜谷氨酰胺转运蛋白抑制剂，以研究阻断谷氨酰胺摄取对食管腺癌（EACC）和硫氧还蛋白相互作用蛋白（TXNIP）的影响
- 谷氨酰胺酶联免疫吸附试验处理根尖和基底外侧区融合分化的未感染人类结肠单层（HCM），研究其效果
- 研究其对 SLC1A5_var 介导的线粒体谷氨酰胺转运抑制的作用
- 研究其对细胞谷胱甘肽水平、细胞活性氧（ROS）水平和线粒体活性氧水平的影响
生化／生理作用
L-谷氨酰对硝基苯胺（GPNA）通常用于阻断谷氨酰胺（Gln）转运蛋白丙氨酸丝氨酸半胱氨酸转运蛋白 2（ASCT2）。它还可以抑制钠依赖性和非依赖性氨基酸转运蛋白。GPNA是γ-谷氨酰转移酶（GGT）底物，在γ-谷氨酰基键的水解和随后的生色剂对硝基苯胺（PNA）的释放中起着关键作用。
基底
γ-谷氨酰胺转肽酶底物
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
Eyeshields, Gloves, type N95 (US)
其他客户在看
Paul L Feingold et al.
Molecular cancer therapeutics, 17(9), 2013-2023 (2018-06-24)
In 2017, an estimated 17,000 individuals were diagnosed with esophageal adenocarcinoma (EAC), and less than 20% will survive 5 years. Positron emission tomography avidity is indicative of high glucose utilization and is nearly universal in EAC. TXNIP blocks glucose uptake
Alessandro Corti et al.
Scientific reports, 9(1), 891-891 (2019-01-31)
L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine (Gln) transporter ASCT2, but recent studies have demonstrated that it is also able to inhibit other sodium-dependent and independent amino acid transporters. Moreover, GPNA is a well known substrate of the
Alessandro Corti et al.
Scientific reports, 9(1), 891-891 (2019-01-31)
L-γ-Glutamyl-p-nitroanilide (GPNA) is widely used to inhibit the glutamine (Gln) transporter ASCT2, but recent studies have demonstrated that it is also able to inhibit other sodium-dependent and independent amino acid transporters. Moreover, GPNA is a well known substrate of the
Karol Dokladny et al.
Metabolites, 11(12) (2021-12-24)
Colonic epithelium-commensal interactions play a very important role in human health and disease development. Colonic mucus serves as an ecologic niche for a myriad of commensals and provides a physical barrier between the epithelium and luminal content, suggesting that communication
Lucía Trilla-Fuertes et al.
BMC cancer, 20(1), 307-307 (2020-04-16)
Metabolomics has a great potential in the development of new biomarkers in cancer and it has experiment recent technical advances. In this study, metabolomics and gene expression data from 67 localized (stage I to IIIB) breast cancer tumor samples were
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