TS Answer: The content of Gramicidins A1, A2, B1, C1 and C2 in G5002 is lot-dependent & is ≥ 95.0 %. The content of Gramicidin A1 is also lot-dependent & is ≥ 60.0 %. Please refer to lot-specific CoA. The % contents of the other Gramicidins are not determined in-house. According to published literature citations, Gramicidin A is pore-forming.
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产品名称
葛米素 来源于解硫胺素芽胞杆菌 （短芽孢杆菌）, Linear polypeptide antibiotic complex. A mixture of gramicidins A, B, C, and D.
质量水平
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
作用机制
cell membrane | interferes
enzyme | inhibits
储存温度
2-8°C
InChI
1S/C99H140N20O17/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83-,84+,85-/m0/s1
InChI key
ZWCXYZRRTRDGQE-SORVKSEFSA-N
生化/生理作用
短杆菌肽A、B、C和D的线性多肽抗生素混合物。短杆菌肽A可充当中性载体，有助于建立跨脂质双层的离子通量。[2]
线性多肽抗生素，即短杆菌肽A、B、C和D的混合物。短杆菌肽D，一个缓慢在膜上翻转的通道形成离子载体，已被发现是一种Pgp底物，并且令人惊讶地发现它可以抑制Pgp ATPase活性。其他Pgp底物可逆转这种抑制作用，表明MDR底物类型的药物和化学增敏剂之间存在共同的药物结合位点。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
其他客户在看
Philipp Rühl et al.
Communications biology, 4(1), 1164-1164 (2021-10-09)
The cellular resting membrane potential (Vm) not only determines electrical responsiveness of excitable cells but also plays pivotal roles in non-excitable cells, mediating membrane transport, cell-cycle progression, and tumorigenesis. Studying these processes requires estimation of Vm, ideally over long periods
Porin channels in Escherichia coli: studies with liposomes reconstituted from purified proteins.
Nikaido H and Rosenberg E Y
Journal of Bacteriology, 153(1), 241-252 (1983)
E J Prenner et al.
Biochimica et biophysica acta, 1462(1-2), 201-221 (1999-12-11)
Gramicidin S (GS) is a cyclic decapeptide of primary structure [cyclo-(Val-Orn-Leu-D-Phe-Pro)(2)] secreted by Bacillus brevis. It is a powerful antimicrobial agent with potent cidal action on a wide variety of Gram-negative and Gram-positive bacteria as well as on several pathogenic
Tatsushi Mogi et al.
Cellular and molecular life sciences : CMLS, 66(23), 3821-3826 (2009-08-25)
Gramicidin S and polymyxins are small cationic cyclic peptides and act as potent antibiotics against Gram-negative and Gram-positive bacteria by perturbing integrity of the bacterial membranes. Screening of a natural antibiotics library with bacterial membrane vesicles identified gramicidin S as
Combined electrochemistry and surface-enhanced infrared absorption spectroscopy of gramicidin A incorporated into tethered bilayer lipid membranes.
Jacek Kozuch et al.
Angewandte Chemie (International ed. in English), 51(32), 8114-8117 (2012-08-07)
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I have a question about this product (gramicidin) - What is the composition/percentage of A, B, C, D in this Gramicidin mix? Which one has the pore-forming activity, A, B, C or D? Thanks!
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