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生物源
human liver
品質等級
無菌
0.2 μm filtered
種類
Type IV
化驗
≥95% (SDS-GE)
形狀
liquid
分子量
H subunit ~21 kDa
L subunit ~19 kDa
~440 kDa (a shell of 24 protein subunits (apoferritin) and a core of Fe3+ ions)
包裝
vial of 2 μg
濃度
10 μg/mL
儲存溫度
2-8°C
基因資訊
human ... FTH1(2495) , FTL(2512) , FTMT(94033)
一般說明
铁蛋白包含24个亚基，属于铁蛋白样双铁羧酸蛋白质超家族。铁蛋白由重链(H)和轻链(L)亚基组成。肝铁蛋白主要由轻链亚基组成，脾为重链。轻链亚基定位于人染色体9q13.33， 重链为11q12.3。
應用
人肝脏铁蛋白已用作体积排阻高效液相色谱中的蛋白模型，并用于合成纳米孔转位研究。还用于检测其对虾（凡纳滨对虾/Litopenaeus vannamei）的白斑综合征病毒易感性的影响。
生化／生理作用
广泛的储铁蛋白在铁代谢中起关键作用。其用作细胞内的铁储备（特别是在脾脏、肝脏、肠粘膜和骨髓中）并参与铁解毒。 研究表明，铁蛋白铁的掺入是由与铁蛋白 H 亚基相关的铁氧化酶活性和与铁蛋白 L 亚基相关的成核中心介导的。 从铁蛋白释放铁在铁依赖性脂质过氧化中具有重要作用，并且可能在体内促成自由基诱导的细胞损伤。因此，通过结合铁，铁蛋白可以起抗氧化剂的作用。
铁蛋白是宿主防御体系的一部分，在动物的抗病毒感染应答中起作用。铁蛋白的异常水平与前列腺、乳腺和大脑等多个部位的肿瘤有关。炎症和巨噬细胞活化综合征(MAS)会导致铁蛋白浓度升高。轻链亚基突变会导致神经退行性疾病、遗传性铁蛋白病。
外觀
溶液，pH 8.0，含10 mM Tris、150 mM NaCl和0.1%叠氮化钠。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
其他客户在看
Yuan-Hwa Ruan et al.
Fish & shellfish immunology, 28(4), 542-548 (2010-01-05)
We examined the physiological (hemolymph glucose, lactate, and lipid) and innate non-specific immune responses (total hemocyte count (THC), phenoloxidase (PO) activity, respiratory bursts (release of superoxide anion, O(2)(-)) and superoxide dismutase (SOD) activity) to white spot syndrome virus (WSSV) in
P Ruscitti et al.
Clinical and experimental immunology, 191(2), 220-228 (2017-09-30)
Macrophage activation syndrome (MAS) is hyperinflammatory life-threatening syndrome, associated typically with high levels of serum ferritin. This is an iron storage protein including heavy (H) and light (L) subunits, categorized on their molecular weight. The H-/L subunits ratio may be
Erik R Anderson et al.
Comprehensive Physiology, 3(1), 315-330 (2013-05-31)
Iron is an essential nutrient that is tightly regulated. A principal function of the liver is the regulation of iron homeostasis. The liver senses changes in systemic iron requirements and can regulate iron concentrations in a robust and rapid manner.
Alexander Michael Dohnal et al.
International journal of cancer, 119(12), 2870-2877 (2006-10-04)
The potential immunogenicity of acute lymphoblastic leukemia of the T cell (T-ALL), a small subgroup of childhood leukemia with increased risk for treatment failure and early relapse, was addressed by serological identification of leukemia-derived antigens by recombinant expression cloning (SEREX).
A novel FTL mutation responsible for neuroferritinopathy with asymmetric clinical features and brain anomalies.
Sébastien Moutton et al.
Parkinsonism & related disorders, 20(8), 935-937 (2014-06-08)
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