F1293

非那雄胺

≥98% (HPLC), powder

• 别名: N-叔丁基-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺, MK-906, N-(2-甲基-2-丙基)-3-氧代-4-氮杂-5α-雄甾-1-烯-17β-甲酰胺
• 经验公式（希尔记法）: C₂₃H₃₆N₂O₂
• CAS号: 98319-26-7
• 分子量: 372.54
• MDL编号: MFCD00869737
• UNSPSC代码: 41116107
• PubChem化学物质编号: 24724479
• NACRES: NA.77

属性

• 方案: ≥98% (HPLC)
• 表单: powder
• 颜色: white to beige
• 溶解性: DMSO: soluble >20 mg/mL
• 储存温度: room temp
• SMILES字符串: [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(=O)NC(C)(C)C)[C@@]4(C)CC[C@]3([H])[C@@]1(C)C=CC(=O)N2
• InChI: 1S/C23H36N2O2/c1-21(2,3)25-20(27)17-8-7-15-14-6-9-18-23(5,13-11-19(26)24-18)16(14)10-12-22(15,17)4/h11,13-18H,6-10,12H2,1-5H3,(H,24,26)(H,25,27)/t14-,15-,16-,17+,18+,22-,23+/m0/s1
• InChI key: DBEPLOCGEIEOCV-WSBQPABSSA-N
• 基因信息: human ... HSD3B1(3283) , SRD5A1(6715) , SRD5A2(6716) ; rat ... Hsd3b1(360348) , Srd5a1(24950) , Srd5a2(64677)

说明

应用

Finasteride has been used:

• as a component of L-15 media to investigate the effects of finasteride exposure on brain, liver and testis tissues
• in culture medium to treat tumor cells in vitro
• as a positive control to treat benign prostatic hyperplasia (BPH)
• to examine its effect on structural and molecular biology on the ventral prostate of senile mice

生化/生理作用

选择性 5α-还原酶抑制剂；抗雄激素。

Finasteride can reduce serum and scalp dihydrotestosterone (DHT) by preventing the transformation of testosterone to DHT. It is usually used to manage benign prostate hyperplasia and pattern hair loss in male. Finasteride possesses androgen-distracting properties.

安全信息

• 象形图: GHS08,GHS07
• 警示用语：: Danger
• 危险声明: H302,H360FD
• 预防措施声明: P202 - P264 - P270 - P280 - P301 + P312 - P308 + P313
• 危险分类: Acute Tox. 4 Oral - Repr. 1B
• 储存分类代码: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• 个人防护装备: dust mask type N95 (US), Eyeshields, Faceshields, Gloves