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Merck
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文件

F0504

Sigma-Aldrich

Folate binding protein from bovine milk

lyophilized powder

别名:

Folate Protein

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About This Item

MDL號碼:
MFCD00131098
分類程式碼代碼:
12352202
NACRES:
NA.61

生物源

bovine milk

形狀

lyophilized powder

用途

1 mg sufficient for ~4,000 assays

成份

Protein, 20-40% modified Warburg-Christian

技術

ligand binding assay: suitable
surface plasmon resonance (SPR): suitable

容量

1.5-6.0 μg/mg, protein binding capacity (folic acid)(25 °C at pH 7.5.)

儲存溫度

−20°C

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應用

Folate binding protein can be used in radioligand binding assays of serum folate. The folate receptor has been used in studies as a therapeutic target in a variety of cancers.
Folate binding protein from bovine milk has been used in folate binding studies using surface plasmon resonance and in the uptake studies in kidney proximal tubule cells.
Useful for radioligand binding assays of serum folate. May also bind N-methyltetrahydrofolic acid and other folate analogues.

生化／生理作用

Folate-binding protein (FBP) is present as a cell receptor and binds to folate in equimolar ratio. It is involved in the transport of folate and improves their bioavailability.

包裝

Package size based on protein content

品質

Purified over 1,000 fold. May contain a trace of β-mercaptoethanol.

外觀

Lyophilized powder containing buffer salt as sodium citrate

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

Not applicable

閃點（°C）

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)

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Dietary interactions influence the effects of bovine folate-binding protein on the bioavailability of tetrahydrofolates in rats
Jones ML, et al.
The Journal of Nutrition, 133(2), 489-495 (2003)
Radioisotopic assay for measurement of serum folate levels.
S Waxman et al.
Blood, 38(2), 219-228 (1971-08-01)
Tetrahydrofolates are greatly stabilized by binding to bovine milk folate-binding protein
Jones ML and Nixon PF
The Journal of Nutrition, 132(9), 2690-2694 (2002)
Nikki Parker et al.
Analytical biochemistry, 338(2), 284-293 (2005-03-05)
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety of cancers. The current development of folate-targeted cancer therapies has created the need for quantitating functional FRs in clinical specimens. In this article, we
Claire Corot et al.
Magnetic resonance in medicine, 60(6), 1337-1346 (2008-11-26)
The objective of this study was to evaluate the potential of a high-relaxivity macromolecular gadolinium (Gd) chelate to target folate receptors (FRs). P866 is a dimeric high-relaxivity Gd chelate coupled to a folate moiety. Binding affinity, in vivo biodistribution studies
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