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D1530

Sigma-Aldrich

1α,25-二羟基维生素D3

≥99% (HPLC)

别名:

1α,25-二羟胆钙化醇, 骨化三醇

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About This Item

经验公式（希尔记法）:
C27H44O3
CAS号:
32222-06-3
分子量:
416.64
Beilstein:
7559394
EC 号:
250-963-8
MDL编号:
MFCD00867079
UNSPSC代码:
12352205
eCl@ss:
34058003
PubChem化学物质编号:
24893473
NACRES:
NA.79
价格与库存信息目前不能提供

质量水平

300

方案

≥99% (HPLC)

表单

solid

技术

HPLC: suitable

储存温度

−20°C

SMILES字符串

[H][C@@]1(CC[C@@]2([H])C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C)[C@H](C)CCCC(C)(C)O

InChI

1S/C27H44O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-11,18,22-25,28-30H,2,6-9,12-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,23-,24+,25+,27-/m1/s1

InChI key

GMRQFYUYWCNGIN-NKMMMXOESA-N

基因信息

human ... VDR(7421)

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相关类别

生化/生理作用

在钙的吸收和沉积中维生素D3的生物活性形式。
在钙的吸收和沉积中维生素D3的生物活性形式。 1α,25-二羟基维生素D3对细胞分化和增殖具有广泛的作用，并可调节免疫应答和中枢神经系统功能。最近的研究表明，1α,25-二羟基维生素D3可作为抵抗包括前列腺癌和结肠癌在内数种恶性肿瘤的化学预防剂，并显示出了与其他抗癌化合物的协同作用。
胆钙化醇是维生素D3的一种失活形式，它在经历各种水平的羟基化后可形成活性的维生素D3类似物。 1α-羟基维生素D3（阿法骨化醇是一种可代谢为1,25-二羟胆钙化醇的合成类似物，它是钙吸收和沉积中维生素D3的生物活性形式。1α,25-二羟基维生素D3对细胞分化和增殖具有广泛的作用，并可调节免疫应答和中枢神经系统功能。最近的研究表明，1α,25-二羟基维生素D3可作为抵抗包括前列腺癌和结肠癌在内数种恶性肿瘤的化学预防剂，并显示出了与其他抗癌化合物的协同作用。

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险分类

Acute Tox. 1 Oral - Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - STOT RE 1

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000132788
0000214504
0000214504
0000132788
0000081421

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Questions

1–6 of 6 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. How can I dissolve Product D1530, ?,25-Dihydroxyvitamin D3, for cell culture use?

    1 answer

    1. 1?,25-Dihydroxyvitamin D3 is soluble in serveral organic solvents, including methanol, ethanol, ethyl acetate, and tetrahydrofuran. For cell culture use, a 10 μM stock solution can be prepared and diluted to the working concentration in cell culture media.

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  4. I can't see anything in the vial. How should Product D1530, 1´,25-Dihydroxyvitamin D3, look?

    1 answer

    1. D1530 is packaged by dispensing a solution into the vials, then drying them under inert gas. The product will be a thin film in the bottom of the vial, so it may appear to be empty by visual inspection.

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  5. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  6. What is the best way to store stock solutions of Product D1530, 1?,25-Dihydroxyvitamin D3?

    1 answer

    1. 1?,25-Dihydroxyvitamin D3 is both air and light sensitive, so should be stored under inert gas at either -20 or -70°C.  The length of time a stock solution can be stored depends on how carefully air is excluded from the solution. If care is taken to exclude air, stock solutions may be stable indefinitely at -20°C.

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