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C1129

Sigma-Aldrich

胆酸

from bovine and/or ovine, ≥98%

别名:

3α,7α,12α-三羟基-5β-胆烷酸, 胆烷酸

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25 G
US$76.85
100 G
US$191.04
500 G
US$500.27
1 KG
US$939.02

US$76.85

国内现货，预计发货时间2025年4月02日详情

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选择尺寸

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25 G
US$76.85
100 G
US$191.04
500 G
US$500.27
1 KG
US$939.02

About This Item

经验公式（希尔记法）:
C24H40O5
CAS号:
81-25-4
分子量:
408.57
Beilstein:
2822009
EC 号:
201-337-8
MDL编号:
MFCD00003672
UNSPSC代码:
12161900
PubChem化学物质编号:
24892356
NACRES:
NA.25

US$76.85

国内现货，预计发货时间2025年4月02日详情

如需订购该产品，请通过联系信息 联系默克当地经销商。

生物来源

bovine and/or ovine

描述

anionic

方案

≥98%

表单

powder

分子量

408.57 g/mol

mp

200-201 °C (lit.)

官能团

carboxylic acid

运输

ambient

储存温度

room temp

SMILES字符串

[H][C@@]12C[C@H](O)CC[C@]1(C)[C@@]3([H])C[C@H](O)[C@]4(C)[C@]([H])(CC[C@@]4([H])[C@]3([H])[C@H](O)C2)[C@H](C)CCC(O)=O

InChI

1S/C24H40O5/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29)/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-/m1/s1

InChI key

BHQCQFFYRZLCQQ-OELDTZBJSA-N

基因信息

human ... CYP1A2(1544)

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相关类别

一般描述

胆酸是肝脏中产生的主要的胆汁酸，其可促进脂肪吸收和胆固醇排泄。 它是一种非变性离子型去污剂。

应用

在一项研究中，膳食胆酸已被用于评估其对结肠上皮细胞增殖的影响。 [1] 它也被用于研究人类红细胞血影的提取和比较。 [2]
用于提取膜蛋白的非变性离子洗涤剂。

生化/生理作用

胆汁酸

储存分类代码

11 - Combustible Solids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000416575
0000416574
0000416575
0000416574
0000312377

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其他客户在看

Slide 1 of 3

1 of 3

脱氧胆酸 ≥99.0% (T)

Sigma-Aldrich

30960

脱氧胆酸

鹅去氧胆酸 European Pharmacopoeia (EP) Reference Standard

C1050000

鹅去氧胆酸

胆汁酸，结合型

Sigma-Aldrich

CBA

胆汁酸，结合型

Hui Zhou et al.
JCI insight, 5(20) (2020-10-16)
High-fat feeding (HFF) leads to gut dysbiosis through unclear mechanisms. We hypothesize that bile acids secreted in response to high-fat diets (HFDs) may act on intestinal Paneth cells, leading to gut dysbiosis. We found that HFF resulted in widespread taxonomic
R Coleman et al.
Biochimica et biophysica acta, 436(1), 38-44 (1976-06-04)
1. Human erythrocyte ghosts were extracted with individual free and conjugated bile salts and, for comparison, with Triton X-100 under conditions approximating to physiological temperature, pH and tonicity. 2. Treatment with cholate, glycocholate, taurocholate, or with Triton X-100 gave lipid-depleted
E E Deschner et al.
Digestion, 21(6), 290-296 (1981-01-01)
Administration of cholic acid (1.0% of the diet) to male Fisher rats for 3 days resulted in increased numbers of DNA synthesizing epithelial cells per colonic crypt column as compared to those found in either control or 0.2% cholic acid-fed
Michael Lazarou et al.
The FEBS journal, 276(22), 6701-6713 (2009-10-22)
Complex IV is the terminal enzyme of the mitochondrial respiratory chain. In humans, biogenesis of complex IV involves the coordinated assembly of 13 subunits encoded by both mitochondrial and nuclear genomes. The early stages of complex IV assembly involving mitochondrial
Yuan Chen et al.
Molecular endocrinology (Baltimore, Md.), 29(4), 613-626 (2015-02-13)
Among diseases unique to pregnancy, intrahepatic cholestasis of pregnancy is the most prevalent disorder with elevated serum bile acid levels. We have previously shown that estrogen 17β-estradiol (E2) transrepresses bile salt export pump (BSEP) through an interaction between estrogen receptor
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实验方案

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

HPLC Separation of Bile Acids with Ascentis Express C18

Investigate bile acid roles in gut hormone profiles and glycemic control, vital for clinical labs exploring potential mechanisms.

相关内容

Bile Acids Kit for LC-MS

Bile Acids (BA) are synthesized in the liver and play important roles in cholesterol homeostasis, absorption of vitamins and lipids, and various key metabolic processes.

Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. Can the cholic acid be frozen once in solution?

    1 answer

    1. Unfortunately, the solution stability of this product has not been determined.

      Helpful?

  4. what is the solubility of cholic acid in DMSO, Ethanol or PBS?

    1 answer

    1. This product is tested for solubility in methanol at 50 mg/mL. Other possible solvents have not been evaluated.

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