推荐产品
生物源
mouse
品質等級
共軛
unconjugated
抗體表格
purified immunoglobulin
抗體產品種類
primary antibodies
無性繁殖
ICRF44, monoclonal
形狀
buffered aqueous solution
分子量
antigen 165-170 kDa
物種活性
human
技術
flow cytometry: 5 μL using 1 × 106 cells
同型
IgG1
UniProt登錄號
運輸包裝
wet ice
儲存溫度
2-8°C
目標翻譯後修改
unmodified
基因資訊
human ... ITGAM(3684)
正在寻找类似产品? 访问 产品对比指南
一般說明
CD11b is also known as Mac-1, CR3, MO-1 and C3bi receptor. It belongs to β 2 integrin family. The gene encodes the integrin α M chain. It is expressed on the surface of circulating monocytes, granulocytes, neutrophils, macrophages, dendritic cells and certain NK cells. It is present in subcellular granules in granulocytes and on subsets of macrophages.
Monoclonal anti-Human CD11b antibody (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human monocytes.
特異性
Recognizes the CD11b α-chain of the human CD11b/CD18 complex. The antibody is useful for studies on cell adhesion and migration and for the detection of leukocyte adhesion deficiencies. It may be used to stain acetone-fixed cryostat sections or cell preparations. The epitope recognized by the antibody is formalin sensitive.
2nd Workshop: code no. M104
3rd Workshop: code no. 202 and 238
4th Workshop: code no. M47
2nd Workshop: code no. M104
3rd Workshop: code no. 202 and 238
4th Workshop: code no. M47
免疫原
human monocytes.
應用
Monoclonal Anti-CD11b antibody produced in mouse has been used in immunostaining and flow cytometry.
生化／生理作用
CD11b/CD18 acts as a receptor for C3bi, clotting factor X, fibrinogen and ICAM-1. It is involved in cell-cell and cell-substrate interactions. It plays a crucial role in several immunological processes as well including leukocyte extravasation and phagocytosis. It also plays an important role in certain coagulation protease cascade and in cell migration.
標靶描述
CD11b α-chain of the human CD11b/CD18 complex is an α/β heterodimeric glycoprotein which belongs to the β2 integrin family. It is also known as Mac-1, CR3, MO-1 and C3bi receptor. CD11b is expressed on the surface of circulating monocytes, granulocytes and certain NK cells and is also present in subsets of macrophages. It functions as a receptor for iC3b, clotting factor X, fibrinogen and ICAM-1.
外觀
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Prenatal hypoxia may aggravate the cognitive impairment and Alzheimer?s disease neuropathology in APPSwe/PS1A246E transgenic mice
Zhang X, et al.
Neurobiology of Aging, 34(3), 663-678 (2013)
George Hajishengallis et al.
Clinical and diagnostic laboratory immunology, 9(2), 403-411 (2002-03-05)
Toll-like receptors (TLRs) are important signal transducers that mediate inflammatory reactions induced by microbes through pattern recognition of virulence molecules such as lipopolysaccharide (LPS) and lipoproteins. We investigated whether proinflammatory cytokine responses induced by certain bacterial protein adhesins may also
Liliane Fossati-Jimack et al.
PloS one, 8(2), e57082-e57082 (2013-03-02)
The CD11b/CD18 integrin (complement receptor 3, CR3) is a surface receptor on monocytes, neutrophils, macrophages and dendritic cells that plays a crucial role in several immunological processes including leukocyte extravasation and phagocytosis. The minor allele of a non-synonymous CR3 polymorphism
HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cells
Tang L, et al,
Oncotarget, 8(16), 27314-27314 (2017)
S D Wright et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(20), 7734-7738 (1988-10-01)
Human polymorphonuclear leukocytes (PMN) have previously been shown to bind to aggregates of fibrin and to fibrinogen-coated surfaces. During their interactions with fibrinogen-coated surfaces, PMN make such close contact with the surface that a portion of the secreted elastase activity
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门