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生物来源
human aorta (normal, tunica intima and tunica media, fibrous plaque-free)
质量水平
包装
pkg of 500,000 cells
制造商/商品名称
Cell Applications, Inc
生长模式
Adherent
核型
2n = 46
形态学
smooth muscle
技术
cell culture | mammalian: suitable
相关疾病
cardiovascular diseases
运输
dry ice
储存温度
−196°C
相关类别
一般描述
Human Aortic Smooth Muscle Cells (HAOSMC) provide an excellent model system to study all aspects of cardiovascular function and disease, especially those related to mechanisms of hyperplasia and hypertrophy of intimal smooth muscle cells leading to vascular occlusion in atherosclerosis and stent restenosis.
HAOSMC have been utilized in dozens of research studies, for example, to:elucidate cytokines and growth factors signaling pathways implicated in the molecular regulation of smooth muscle cell proliferation, migration, and overall vascular function (Liu, 2009; Tan, 2009; Seymour, 2010; Chen, 2011; Hirase, 2013; Stein, 2013):
- Understand hyperglycemia-related risk factors for atherosclerosis in diabetes patients (Maier, 2010), as well as effects of ethanol on vascular calcification (Oros, 2012)
- Investigate extracellular elastic matrix deposition and its role in cardiovascular health, repair of damaged vasculature and successful tissue engineering (Gacchina, 2010, 2011; Venkataraman, 2012; Phillippi, 2013)
- Study mechanisms and effects of mechanoregulation on proliferation and function of smooth muscle cells (Jiang, 2009; Venkataraman, 2013, 2014), and develop advanced stent technology, including novel surface materials, and drug and gene delivery systems to prevent restenosis and other occlusive vasculopathies (Brito, 2010; Deshpande, 2013; Kakade, 2013; Lamichhane, 2013)
Characterization: Positive for smooth muscle cell specific alpha-actin expression.
细胞系来源
应用
制备说明
- Can be cultured at least 16 doublings
传代培养常规
免责声明
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
其他客户在看
实验方案
Technical information for working with human aortic smooth muscle cells including thawing, subculturing and cryopreservation.
Technical information for working with human aortic smooth muscle cells including thawing, subculturing and cryopreservation.
Technical information for working with human aortic smooth muscle cells including thawing, subculturing and cryopreservation.
Technical information for working with human aortic smooth muscle cells including thawing, subculturing and cryopreservation.
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