311R-1

PAX-2 (EP235) Rabbit Monoclonal Primary Antibody

• UNSPSC代码: 12352203
• NACRES: NA.41

属性

• 生物来源: rabbit
• 质量水平: 100; 500
• 偶联物: unconjugated
• 抗体形式: culture supernatant
• 抗体产品类型: primary antibodies
• 克隆: EP235, monoclonal
• 描述: (For In Vitro Diagnostic Use in Select Regions (See Chart))
• 表单: buffered aqueous solution
• 种属反应性: human
• 包装: bottle of 1.0 mL predilute (311R-17); bottle of 7.0 mL predilute (311R-18); vial of 0.1 mL concentrate (311R-14); vial of 0.5 mL concentrate (311R-15); vial of 1.0 mL concentrate (311R-16)
• 制造商/商品名称: Cell Marque^®
• 技术: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50
• 同位素/亚型: IgG
• 运输: wet ice
• 储存温度: 2-8°C
• 基因信息: human ... PAX2(5076)

说明

一般描述

PAX-2 is a homeogene strongly expressed during kidney development. PAX-2 gene is expressed in the metanephric mesenchyma after ureter bud induction and is a key factor for the mesenchyma-epithelium conversion. Animals transgenic for PAX-2 have severe renal abnormalities and cysts but no solid tumoral features. The oncogenic potential of the PAX gene family has been reported <em>in vitro</em> with transformation of cell cultures and <em>in vivo</em> with cell injections in nude mice. Gnarra et al. showed PAX-2 expression in renal carcinoma cell lines and underlined its potential role in cell proliferation in these lines.¹ Mazal et al. demonstrated PAX-2 nuclear expression in 88% of clear cell renal cell carcinomas as well as 18% of papillary renal cell carcinoma, and 13% of chromophobe renal cell carcinomas.² More recently, Chivukula et al. demonstrated utility in distinguishing ovarian serous papillary carcinoma (anti-PAX-2 positive) from breast carcinoma (anti-PAX-2 negative).³

质量

IVD

IVD

IVD

RUO

联系

PAX-2 Positive Control Slides, Product No. 311S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

外形

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

制备说明

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

其他说明

For Technical Service please contact: 800-665-7284 or email: [email protected]

法律信息

Cell Marque is a registered trademark of Merck KGaA, Darmstadt, Germany