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Key Documents

426R-1

Sigma-Aldrich

STAT6 (EP325) Rabbit Monoclonal Primary Antibody

别名:

Signal Transducer and Activator of Transcription

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About This Item

分類程式碼代碼:
12352203

生物源

rabbit

品質等級

100
500

共軛

unconjugated

抗體表格

culture supernatant

抗體產品種類

primary antibodies

無性繁殖

EP325, monoclonal

描述

For In Vitro Diagnostic Use in Select Regions

形狀

buffered aqueous solution

物種活性

human

包裝

vial of 0.1 mL concentrate (426R-14)
vial of 0.1 mL concentrate Research Use Only (426R-14-RUO)
vial of 0.5 mL concentrate (426R-15)
vial of 1.0 mL concentrate (426R-16)
vial of 1.0 mL concentrate Research Use Only (426R-16-RUO)
vial of 1.0 mL pre-dilute Research Use Only (426R-17-RUO)
vial of 1.0 mL pre-dilute ready-to-use (426R-17)
vial of 7.0 mL pre-dilute ready-to-use (426R-18)
vial of 7.0 mL pre-dilute ready-to-use Research Use Only (426R-18-RUO)

製造商／商標名

Cell Marque™

技術

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:25-1:100 (concentrated)

同型

IgG

控制

solitary fibrous tumor

運輸包裝

wet ice

儲存溫度

2-8°C

視覺化

nuclear

基因資訊

human ... STAT6(6778)

相关类别

一般說明

STAT6, a member of the signal transducers and activators of transcription (STAT) family, has been found to form recurrent fusions with NAB2 on chromosome 12q13 in the majority of solitary fibrous tumors. Inactivated STAT6 can be found in the form of a dimer located in the cytoplasm. STAT6 and NAB2 fusion enables cytosolic STAT6 to migrate to the nucleus and thus allowing for detection in immunohistochemical assays. NAB2-STAT6 fusion transcriptions have been reported in the majority of solitary fibrous tumors but not in meningiomas, hemangioblastomas, schwannomas, and hemangiomas. This makes STAT6 a useful marker in distinguishing solitary fibrous tumors from other morphologically similar tumors.

品質


IVD
IVD
IVD
RUO

外觀

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide.

準備報告

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Note: This IFU may not apply to your specific product lot.

其他說明

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

法律資訊

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

Not applicable

閃點（°C）

Not applicable

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Alison L Cheah et al.
Pathology, 46(5), 389-395 (2014-07-01)
Recurrent NAB2-STAT6 gene fusions have recently been identified in solitary fibrous tumour by next generation sequencing. Our aim was to examine the sensitivity and specificity of STAT6 immunohistochemistry for solitary fibrous tumour versus other morphologically similar soft tissue tumours. STAT6
Christian Koelsche et al.
Histopathology, 65(5), 613-622 (2014-04-08)
Nuclear relocation of STAT6 has been shown in tumours with NAB2-STAT6 fusion, and has been proposed as an ancillary marker for the diagnosis of solitary fibrous tumours (SFTs). The aim of this study was to verify the utility of STAT6
Leonille Schweizer et al.
Acta neuropathologica, 125(5), 651-658 (2013-04-12)
Non-central nervous system hemangiopericytoma (HPC) and solitary fibrous tumor (SFT) are considered by pathologists as two variants of a single tumor entity now subsumed under the entity SFT. Recent detection of frequent NAB2-STAT6 fusions in both, HPC and SFT, provided

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