SBR00025

Novobiocin Ready Made Solution

100 mg/mL in water

• 别名: Novobiocin Ready Made Solution
• 线性分子式: C₃₁H₃₅N₂NaO₁₁
• 分子量: 634.61
• UNSPSC代码: 51286504
• NACRES: NA.76

属性

• 生物来源: microbial
• 方案: ≥90%
• 表单: liquid
• 浓度: 100 mg/mL in water
• 颜色: faint yellow to dark brown
• 抗生素抗菌谱: Gram-negative bacteria; Gram-positive bacteria; mycobacteria; neoplastics
• 作用机制: DNA synthesis | interferes; enzyme | inhibits
• 储存温度: −20°C

说明

一般描述

Novobiocin, also known as albamycin or cathomycin, is an aminocoumarin antibiotic commonly derived from Streptomyces Sp. It exerts its antibacterial activity by inhibiting Topo II α, which corresponds to bacterial DNA gyrase. It is effective against both gram-positive and gram-negative bacteria and is significant in research involving highly beta-lactam-resistant pneumococcal infections and anti-orthopoxvirus applications. Functioning as a competitive inhibitor in the ATPase reaction catalyzed by GyrB, Novobiocin is employed in microbiology and cell biology research to effectively prevent the growth of bacterial contaminants.

应用

Novobiocin has been used:

• in cell culture systems to treat mycoplasma contaminations.[3]
• in a research to where it has exhibited anti-cancer effects by inhibition of Hsp90 (heat shock protein)[4],[5]

生化/生理作用

Mode of Action: Inhibits DNA synthesis by inhibiting the enzyme Topoisomerase II

Activity spectrum: Active against gram-positive and gram-negative bacteria

特点和优势

• Ready available solution reduce the need for preparation time
• Commonly used in Cell Biology and Biochemical applications
• High quality antibiotic suitable for mulitple research applications

制备说明

Novobiocin Ready Made Solution is light sensitive. Thaw this product at room temperature. It is recommended to avoid repeated freeze thaw cycles of this product. The suggested concentration of Novobiocin for cell culture assays is 50-1000 μg/mL,^[1],[2],[3] therefore, it is recommended to dilute the Ready Made Solution 1:100-2000.

其他说明

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安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H317
• 预防措施声明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危险分类: Skin Sens. 1
• 储存分类代码: 12 - Non Combustible Liquids
• WGK: WGK 1
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable