PHR1442

氟尼辛葡甲胺

Pharmaceutical Secondary Standard; Certified Reference Material

• 别名: 氟尼辛葡甲胺, 2-[[2-甲基-3-（三氟甲基）苯基]氨基] -3-吡啶羧酸葡甲胺盐, 氟尼辛甲葡胺
• 经验公式（希尔记法）: C₁₄H₁₁F₃N₂O₂·C₇H₁₇NO₅
• CAS号: 42461-84-7
• 分子量: 491.46
• EC 号: 255-836-0
• MDL编号: MFCD01725419
• UNSPSC代码: 41116107
• PubChem化学物质编号: 329822603
• NACRES: NA.24

属性

• 等级: certified reference material; pharmaceutical secondary standard
• 质量水平: 300
• Agency: traceable to Ph. Eur. Y0000443; traceable to USP 1274607
• API类: flunixin
• CofA: current certificate can be downloaded
• 包装: pkg of 1 g
• 技术: HPLC: suitable; gas chromatography (GC): suitable
• 应用: pharmaceutical (small molecule)
• 包装形式: neat
• 储存温度: 2-30°C
• SMILES字符串: CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.Cc1c(Nc2ncccc2C(O)=O)cccc1C(F)(F)F
• InChI: 1S/C14H11F3N2O2.C7H17NO5/c1-8-10(14(15,16)17)5-2-6-11(8)19-12-9(13(20)21)4-3-7-18-12;1-8-2-4(10)6(12)7(13)5(11)3-9/h2-7H,1H3,(H,18,19)(H,20,21);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1
• InChI key: MGCCHNLNRBULBU-WZTVWXICSA-N

说明

一般描述

Flunixin meglumine is a nonsteroidal anti-inflammatory drug and a potent cyclo-oxygenase (COX) inhibitor. It is commonly used as an analgesic and antipyretic in animals.[1]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

应用

氟尼辛葡甲胺（IC₅₀ = 1 nM）可用作动物药物，用于治疗马的肠缺血、绞痛和内毒素血症。

Flunixin meglumine may be used as a pharmaceutical reference standard for the determination of the analyte in bulk drug and pharmaceutical formulations by spectrophotometry[2] and high performance liquid chromatography.[3][4]

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

生化/生理作用

COX1、COX2 和 PLA2 抑制剂非麻醉性镇痛、解热、抗炎。

分析说明

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

其他说明

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

附注

To see an example of a Certificate of Analysis for this material enter LRAA2750 in the slot below. This is an example certificate only and may not be the lot that you receive.

安全信息

• 象形图: GHS07
• 警示用语：: Warning
• 危险声明: H315,H319,H335
• 预防措施声明: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• 危险分类: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• 靶器官: Respiratory system
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable