推荐产品
生物来源
mouse
质量水平
偶联物
ALEXA FLUOR™ 647
抗体形式
purified antibody
抗体产品类型
primary antibodies
克隆
12D10, monoclonal
种属反应性
human
浓度
0.5 mg/mL
技术
immunocytochemistry: suitable
运输
wet ice
靶向翻译后修饰
unmodified
一般描述
嘌呤霉素是一种氨基核苷酸抗生素，来源于白黑链霉菌，是蛋白合成抑制剂，可通过核糖体中的过早链终止来阻止翻译。抗嘌呤霉素的单克隆抗体可与标准免疫化学方法一起用于直接监测翻译，这种方法称为翻译表面感应（SUnSET）。该分子的一部分类似于氨基酰化tRNA的3′端，这使其可用于蛋白质翻译分析。嘌呤霉素诱导胸腺细胞和HL-60白血病细胞内DNA断裂。
该抗嘌呤霉素（克隆12D10）抗体经过免疫细胞化学应用验证，可用于检测嘌呤霉素。
特异性
与嘌呤霉素预孵育时，预期与所有物种细胞发生反应。
质量
通过免疫细胞化学分析未处理和嘌呤霉素处理的HeLa细胞进行评估。
免疫细胞化学分析：用该抗体的1:2,500稀释液在嘌呤霉素处理的HeLa细胞中检测掺入嘌呤霉素的新合成蛋白。
Alexa Fluor™是Life Technologies的注册商标。
免疫细胞化学分析：用该抗体的1:2,500稀释液在嘌呤霉素处理的HeLa细胞中检测掺入嘌呤霉素的新合成蛋白。
Alexa Fluor™是Life Technologies的注册商标。
目标描述
请参阅货号MABE343了解观测到的分子量信息。
法律信息
ALEXA FLUOR is a trademark of Life Technologies
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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The British journal of nutrition, 1-11 (2023-05-29)
Se deficiency causes impaired growth of fish skeletal muscle due to the retarded hypertrophy of muscle fibres. However, the inner mechanisms remain unclear. According to our previous researches, we infer this phenomenon is associated with Se deficiency-induced high concentration of
Hongcheng Cheng et al.
Nature metabolism, 5(2), 314-330 (2023-01-31)
The accumulation of acidic metabolic waste products within the tumor microenvironment inhibits effector functions of tumor-infiltrating lymphocytes (TILs). However, it remains unclear how an acidic environment affects T cell metabolism and differentiation. Here we show that prolonged exposure to acid
Noga Ron-Harel et al.
Cell reports, 28(12), 3011-3021 (2019-09-19)
T cell stimulation is metabolically demanding. To exit quiescence, T cells rely on environmental nutrients, including glucose and the amino acids glutamine, leucine, serine, and arginine. The expression of transporters for these nutrients is tightly regulated and required for T cell activation.
Seema Qamar et al.
Cell, 173(3), 720-734 (2018-04-21)
Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we report that cooperative cation-π interactions between tyrosines in the
Michal Scur et al.
Nature communications, 13(1), 7272-7272 (2022-11-27)
Alveolar macrophages (AM) hold lung homeostasis intact. In addition to the defense against inhaled pathogens and deleterious inflammation, AM also maintain pulmonary surfactant homeostasis, a vital lung function that prevents pulmonary alveolar proteinosis. Signals transmitted between AM and pneumocytes of
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