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生物源
rabbit
品質等級
抗體表格
affinity isolated antibody
抗體產品種類
primary antibodies
無性繁殖
polyclonal
純化經由
affinity chromatography
物種活性
rat
物種活性（以同源性預測）
bovine (based on 100% sequence homology)
技術
ELISA: suitable
immunohistochemistry: suitable
western blot: suitable
NCBI登錄號
UniProt登錄號
運輸包裝
wet ice
目標翻譯後修改
unmodified
基因資訊
rat ... Drd1(24316)
一般說明
Dopaminergic signals are thought to modulate corticostriatal synapses onto medium spiny projection neurons, and this plasticity is, in turn, thought to alter patterns of activity during learning. Subversion of these processes in clinical and rodent models is hypothesized to contribute importantly to addiction to psychostimulants, seizures, and movement disorders in Huntington’s (HD) and Parkinson’s disease (PD). Dopamine receptor D1, also known as DRD1, is the most abundant dopamine receptor (of the five types D1-D5) in the central nervous system and is critically involved in these processes and the modulation of D2 receptor mediated events. Coupled with G-protein, the D1a receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases including the key molecular switch, DARPP-32.
特異性
This antibody recognizes D(1A) dopamine receptor.
免疫原
Epitope: Cytoplasmic Domain
KLH-conjugated linear peptide of rat dopamine D(1A) receptor at and around the cytoplasmic domain.
應用
Anti-Dopamine D(1A) Receptor Antibody detects level of Dopamine D(1A) Receptor & has been published & validated for use in IH, WB, ELISA.
Immunohistochemistry Analysis: A 1:300 dilution from a previous lot detected D(1A) dopamine receptor in rat brain tissue.
ELISA Analysis: Tested in ELISA against antigen-coated plate. A 1:100 dilution from a previous lot detected dopamine D(1A) receptor peptide.
ELISA Analysis: Tested in ELISA against antigen-coated plate. A 1:100 dilution from a previous lot detected dopamine D(1A) receptor peptide.
Research Category
Neuroscience
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurotransmitters & Receptors
品質
Evaluated by Western Blot in rat testis tissue lysate.
Western Blot Analysis: 2 µg/ml of this antibody detected dopamine D(1A) receptor in 10 µg of rat testis tissue lysate.
Western Blot Analysis: 2 µg/ml of this antibody detected dopamine D(1A) receptor in 10 µg of rat testis tissue lysate.
標靶描述
~ 55 kDa is observed
聯結
Replaces: AB1765P;
外觀
Affinity purified
Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
儲存和穩定性
Stable for 1 year at 2-8°C from date of receipt.
分析報告
Control
Rat testis tissue lysate
Rat testis tissue lysate
其他說明
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
Gregory N Ruegsegger et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 31(12), 5371-5383 (2017-08-11)
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Evidence suggests that nicotine and alcohol can each serve as a gateway drug. We determined whether prior nicotine and alcohol treatment would alter amphetamine reward. Also, we examined whether age and dopaminergic neurotransmission are important in this regard. Male and
Silvana Obici et al.
Molecular metabolism, 4(10), 692-705 (2015-10-27)
Melanocortin-4 receptors (MC4Rs) are highly expressed by dopamine-secreting neurons of the mesolimbic tract, but their functional role has not been fully resolved. Voluntary wheel running (VWR) induces adaptations in the mesolimbic dopamine system and has a myriad of long-term beneficial
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Staffend, NA; Hedges, VL; Chemel, BR; Watts, VJ; Meisel, RL
Brain Structure &Amp; Function null
Dafna Lotan et al.
PloS one, 9(6), e101257-e101257 (2014-07-01)
Post-streptococcal A (GAS) sequelae including movement and neuropsychiatric disorders have been associated with improvement in response to antibiotic therapy. Besides eradication of infection, the underlying basis of attenuation of neuropsychiatric symptoms following antibiotic treatment is not known. The aim of
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