8.52369

Fmoc-D-Lys(ivDde)-OH

Novabiochem^®

• 别名: Fmoc-D-Lys(ivDde)-OH, N-α-Fmoc-N-ε-1-(4,4-dimethyl-2,6-dioxocyclohex-1-ylidene)-3methylbutyl-D-lysine
• 经验公式（希尔记法）: C₃₄H₄₂N₂O₆
• CAS号: 1272755-33-5
• 分子量: 574.71
• MDL编号: MFCD06796894
• UNSPSC代码: 12352209
• NACRES: NA.22

属性

• 质量水平: 200
• 产品线: Novabiochem^®
• 表单: powder
• 反应适用性: reaction type: Fmoc solid-phase peptide synthesis
• 制造商/商品名称: Novabiochem^®
• 应用: peptide synthesis
• 官能团: amine
• 储存温度: 15-25°C
• SMILES字符串: N([C@H](CCCCNC(=C4C(=O)CC(CC4=O)(C)C)CC(C)C)C(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI: 1S/C34H42N2O6/c1-21(2)17-28(31-29(37)18-34(3,4)19-30(31)38)35-16-10-9-15-27(32(39)40)36-33(41)42-20-26-24-13-7-5-11-22(24)23-12-6-8-14-25(23)26/h5-8,11-14,21,26-27,35H,9-10,15-20H2,1-4H3,(H,36,41)(H,39,40)/t27-/m1/s1
• InChI key: PYCBVLUBTMHNPW-HHHXNRCGSA-N

说明

一般描述

This orthogonally-protected lysine derivative is based on the hindered Dde variant ivDde. It has very similar chemical properties to Fmoc-Lys(Dde)-OH, except that the side-chain ivDde group is considerably more stable to piperidine than Dde, and is less prone to migrate from protected to unprotected lysine side-chains. When removing ivDde in the presence of allyl based protecting groups, allyl alcohol should be included in the deprotection solution to prevent reduction of the allyl group.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Guide to Selection of Orthogonally-Protected Building Blocks for Fmoc SPPS

分析说明

Colour (visual): white to slightly yellow
Appearance of substance (visual): powder
Identity (IR): passes test
Purity (TLC(011A)): ≥ 98 %
Enantiomeric purity: ≥ 99.5 % (a/a)
Assay (HPLC, area%): ≥ 98.0 % (a/a)
Solubility (1 mmole in 2 ml DMF): clearly soluble

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable