8.52201

Fmoc-Phe-Thr(psiMe,Mepro)-OH

Novabiochem^®

• 别名: Fmoc-Phe-Thr(psiMe,Mepro)-OH
• 经验公式（希尔记法）: C₃₁H₃₂N₂O₆
• 分子量: 528.60
• UNSPSC代码: 12352209
• NACRES: NA.22

属性

• 质量水平: 200
• 产品线: Novabiochem^®
• 方案: ≥97% (TLC); ≥97.0% (HPLC)
• 表单: powder
• 反应适用性: reaction type: Fmoc solid-phase peptide synthesis
• 制造商/商品名称: Novabiochem^®
• 应用: peptide synthesis
• 官能团: hydroxyl
• 储存温度: 2-8°C

说明

一般描述

This pseudoproline dipeptide is undoubtedly the most effective and simplest to use tool for overcoming aggregation and enhancing peptide quality in Fmoc SPPS for peptide containing the Phe-Thr dipeptide motif. It consists of a dipeptide in which the threonine residue has been reversibly protected as a structure-breaking proline-like TFA-labile oxazolidine. The reason the pseudoproline residue is introduced as a dipeptide is because it avoids the need to acylate the hindered oxazolidine nitrogen. This has the added advantage of extending the peptide chain by two residues in one step. The threonine residue is regenerated during the normal TFA-mediated cleavage reaction.

Associated Protocols and Technical Articles
Cleavage and Deprotection Protocols for Fmoc SPPS
Overcoming Aggregation in Fmoc SPPS

联系

Replaces: 05-20-1128

分析说明

Color (visual): white to slight yellow to beige
Appearance of substance (visual): powder
Identity (IR): passes test
Optical rotation α 25/D (c=1 in methanol): -29.0 - -23.0 °
Purity (TLC(157A)): ≥ 97 %
Assay (HPLC, area%): ≥ 97.0 % (a/a)
Acetate (IC): ≤ 0.1 %
Ethyl acetate (HS-GC): ≤ 2.0 %

To see the solvent systems used for TLC of Novabiochem^® products please click here.

法律信息

Novabiochem is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 2
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable