567726

D-erythro-Sphingosine, Free Base, High Purity

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer.

• 别名: D-erythro-Sphingosine, Free Base, High Purity, Cerebroside, trans-D- erythro-2-Amino-4-octadecene-1,3-diol, Ceramide, Cerebroside, trans-D-erythro-2-Amino-4-octadecene-1,3-diol, Ceramide
• 经验公式（希尔记法）: C₁₈H₃₇NO₂
• CAS号: 123-78-4
• 分子量: 299.49
• MDL编号: MFCD00036751
• UNSPSC代码: 12352211
• NACRES: NA.77

属性

• 质量水平: 100
• 描述: Merck USA index - 14, 8747
• 方案: ≥98% (TLC)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze
• 颜色: white
• 溶解性: chloroform: 1 mg/mL; methanol: 1 mg/mL; DMSO: 10 mg/mL
• 运输: ambient
• 储存温度: −20°C
• SMILES字符串: N[C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO
• InChI: 1S/C18H37NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h14-15,17-18,20-21H,2-13,16,19H2,1H3/b15-14+/t17-,18+/m0/s1
• InChI key: WWUZIQQURGPMPG-KRWOKUGFSA-N

说明

一般描述

Highly purified preparation of bovine brain sphingosine containing >99% of the erythro isomer. A potent, cell-permeable, reversible, and selective inhibitor of protein kinase C (PKC; IC₅₀ = 2.8 µM) and insulin receptor tyrosine kinase. PKC inhibition is competitive with respect to diacylglycerol, phorbol dibutyrate, and Ca²⁺. Does not affect the activity of myosin light chain kinase and protein kinase A. Induces apoptosis in human leukemia HL-60 cells. Note: This product is not to be used for animal treatment, in vivo research or in any other contact procedure with livestock.

生化/生理作用

Cell permeable: no

Primary Target
PKC

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2.8 µM against PKC

警告

Toxicity: Irritant (B)

重悬

Following reconstitution, aliquot, purge with N₂ gas, and freeze (-20°C). Stock solutions are stable for up to 6 months under inert atmosphere at -20°C.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 危险声明: H413
• 预防措施声明: P273 - P501
• 危险分类: Aquatic Chronic 4
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable