530050-M

PRIMA-1

A cell-permeable quinuclidinone analog with antitumor properties.

• 别名: PRIMA-1, 2,2-Bis(hydroxymethyl)-1-azabicyclo[2,2,2]octan-3-one, p53 Reactivation and Induction of Massive Apoptosis
• 经验公式（希尔记法）: C₉H₁₅NO₃
• CAS号: 5608-24-2
• 分子量: 185.22
• MDL编号: MFCD04974196
• UNSPSC代码: 12352200

属性

• 质量水平: 100
• 方案: ≥95% (NMR)
• 表单: solid
• 制造商/商品名称: Calbiochem^®
• 储存条件: OK to freeze; desiccated (hygroscopic)
• 颜色: off-white
• 溶解性: water: 2 mg/mL
• 储存温度: 2-8°C
• SMILES字符串: N21CCC(CC2)C(=O)C1(CO)CO
• InChI: 1S/C9H15NO3/c11-5-9(6-12)8(13)7-1-3-10(9)4-2-7/h7,11-12H,1-6H2
• InChI key: RFBVBRVVOPAAFS-UHFFFAOYSA-N

说明

一般描述

A cell-permeable quinuclidinone analog with anti-tumor properties. Induces p53-dependent apoptosis in human tumor cells through restoration of the transcriptional transactivation function to mutant p53. Restores sequence-specific DNA binding and active conformation to mutant p53 proteins in vitro and in living cells. Suppresses tumor growth in mice with no apparent toxicity. Induces apoptosis in breast cancer cells expressing mutant p53.

生化/生理作用

Primary Target
Restores biochemical and biological function to mutant p53

警告

Toxicity: Standard Handling (A)

其他说明

Bykov, V.J., et al. 2002. Nat. Med.8, 282.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全信息

• 象形图: GHS08,GHS07
• 警示用语：: Danger
• 危险声明: H302,H334
• 预防措施声明: P261 - P264 - P270 - P284 - P301 + P312 - P501
• 危险分类: Acute Tox. 4 Oral - Resp. Sens. 1
• 储存分类代码: 11 - Combustible Solids
• WGK: WGK 3
• 闪点(°F): Not applicable
• 闪点(°C): Not applicable