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产品名称
PP2, InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases
品質等級
化驗
≥95% (HPLC)
形狀
liquid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
clear colorless
運輸包裝
wet ice
儲存溫度
−20°C
一般說明
A potent and selective inhibitor of the src family of tyrosine kinases. Its action is similar to PP1. Selectively inhibits p56lck (IC50 = 4 nM), p59fynT (IC50 = 5 nM), and Hck (IC50 = 5 nM) compared to other tyrosine kinases, such as EGF-R (IC50 = 480 nM), JAK2 (IC50 >50 µM) or ZAP-70 (IC50 >100 µM). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC50 = 600 nM).
生化／生理作用
Cell permeable: no
Primary Target
p56lck
p56lck
Product competes with ATP.
Reversible: yes
Target IC50: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells
包裝
Packaged under inert gas
警告
Toxicity: Irritant (B)
外觀
A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529573) in DMSO.
重構
Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
其他說明
Hanke, J.H., et al. 1996. J. Biol. Chem.271, 695.
Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.
Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
188.6 °F - closed cup - (Dimethylsulfoxide)
閃點（°C）
87 °C - closed cup - (Dimethylsulfoxide)
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